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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Adenine arabinoside 5′‐monophosphate treatment of chronic type B hepatitis
Hepatology, Volume 2, No. 6, Year 1982
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Description
Six patients with chronic type B hepatitis were treated with adenine arabinoside 5′‐monophosphate at a dosage of 10 to 15 mg per kg per day for 10 days. All demonstrated an immediate and marked decrease in serum hepatitis B virus DNA and DNA polymerase, and 5 of the 6 became negative for both markers by the end of the period of therapy. One patient remained negative for hepatitis B virus DNA and DNA polymerase when therapy was discontinued. This patient subsequently exhibited clinical, serum biochemical, and histological remission in disease activity concurrent with seroconversion from hepatitis B e antigen to antibody. In the remaining five patients, serum hepatitis B virus DNA and DNA polymerase returned to pretreatment values soon after therapy was stopped, and these patients demonstrated no significant changes in clinical, biochemical, serological, or histological features of the disease. Side effects of the therapy were mild and transient. These results suggest that a 10‐day course of adenine arabinoside 5′‐monophosphate is not adequate to induce permanent amelioration of infection and disease activity in the majority of patients with chronic type B hepatitis. Copyright © 1982 American Association for the Study of Liver Diseases
Authors & Co-Authors
Minuk, Gerald Yosel
United States, Bethesda
National Institutes of Health Nih
United States, Washington, D.c.
Georgetown University School of Medicine
United States, Arlington
United States Department of Defense
Dusheiko, Geoffrey M.
United States, Bethesda
National Institutes of Health Nih
United States, Washington, D.c.
Georgetown University School of Medicine
United States, Arlington
United States Department of Defense
Straus, Stephen E.
United States, Bethesda
National Institutes of Health Nih
United States, Washington, D.c.
Georgetown University School of Medicine
United States, Arlington
United States Department of Defense
Gerin, John L.
United States, Bethesda
National Institutes of Health Nih
United States, Washington, D.c.
Georgetown University School of Medicine
United States, Arlington
United States Department of Defense
Statistics
Citations: 35
Authors: 4
Affiliations: 3
Identifiers
Doi:
10.1002/hep.1840020606
ISSN:
02709139
Research Areas
Genetics And Genomics
Health System And Policy
Infectious Diseases