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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Association of adiponectin promoter variants with traits and clusters of metabolic syndrome in Arabs: Family-based study
Gene, Volume 527, No. 2, Year 2013
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Description
Plasma levels of adiponectin are decreased in type 2 diabetes, obesity and hypertension. Our aim was to use a family-based analysis to identify the genetic variants of the adiponectin (ADIPOQ) gene that are associated with obesity, insulin resistance, dyslipidemia and hypertension, among Arabs. We screened 328 Arabs in one large extended family for single nucleotide polymorphisms (SNPs) in the promoter region of the ADIPOQ gene. Two common SNPs were detected: rs17300539 and rs266729. Evidences of association between traits related to the metabolic syndrome and the SNPs were studied by implementing quantitative genetic association analysis. Results showed that SNP rs266729 was significantly associated with body weight (p-value = 0.001), waist circumference (p-value = 0.037), BMI (p-value = 0.015) and percentage of total body fat (p-value = 0.003). Up to 4.1% of heritability of obesity traits was explained by the rs266729 locus. Further cross-sectional analysis showed that carriers of the G allele had significantly higher values of waist circumference, BMI and percentage of total body fat (p-values 0.014, 0.004 and 0.032, respectively). No association was detected between SNP rs266729 and other clusters of metabolic syndrome or their traits except for HOMA-IR and fasting plasma insulin levels, p-values 0.035 and 0.004, respectively. In contrast, both measured genotype and cross-sectional analysis failed to detect an association between the SNP rs17300539 with traits and clusters of metabolic syndrome. In conclusion, we showed family-based evidence of association of SNP rs266729 at ADIPOQ gene with traits defining obesity in Arab population. This is important for future prediction and prevention of obesity in population where obesity is in an increasing trend. © 2013 Elsevier B.V.
Authors & Co-Authors
Zadjali, Fahad
Oman, Muscat
Sultan Qaboos University
Al-Yahyaee, Said Ali S.
Oman, Muscat
Sultan Qaboos University
Hassan, Mohammed Othman
Oman, Muscat
Sultan Qaboos University
Albarwani, Sulayma
Oman, Muscat
Sultan Qaboos University
Bayoumi, Riad A.L.
Oman, Muscat
Sultan Qaboos University
Statistics
Citations: 27
Authors: 5
Affiliations: 1
Identifiers
Doi:
10.1016/j.gene.2013.06.057
ISSN:
18790038
Research Areas
Genetics And Genomics
Noncommunicable Diseases
Study Design
Cross Sectional Study
Study Approach
Quantitative