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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Effect of multivitamin supplementation on measles vaccine response among HIV-exposed uninfected Tanzanian infants
Clinical and Vaccine Immunology, Volume 20, No. 8, Year 2013
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Description
Immunization and nutritional interventions are mainstays of child health programs in sub-Saharan Africa, yet few published data exist on their interactions. HIV-exposed (but uninfected) infants enrolled in a randomized placebo-controlled trial of multivitamin supplements (vitamins B complex, C, and E) conducted in Tanzania were sampled for an assessment of measles IgG quantity and avidity at 15 to 18 months. Infants were vaccinated between 8.5 and 12 months of age, and all mothers received high-dose multivitamins as the standard of care. Of 201 HIV-exposed infants who were enrolled, 138 (68.7%) were seropositive for measles. There were no effects of infant multivitamin supplementation on measles seroconversion proportions, IgG concentrations, or IgG avidity (P>0.05). The measles seroconversion proportion was greater for HIV-exposed infants vaccinated at 10 to 11 months of age than for those vaccinated at 8.5 to 10 months (P=0.032) and greater for infants whose mothers had a CD4 T-cell count of<200 cells/μl than for infants whose mothers had a CD4 T-cell count of>350 cells/μl (P=0.039). Stunted infants had a significantly decreased IgG quantity compared to nonstunted infants (P=0.012). As for measles avidity, HIV-exposed infants vaccinated at 10 to 11 months had increased antibody avidity compared to those vaccinated at 8.5 to 10 months (P=0.031). Maternal CD4 T-cell counts of<200 cells/μl were associated with decreased avidity compared to counts of>350 cells/μl (P=0.047), as were lower infant height-for-age z-scores (P=0.016). Supplementation with multivitamins containing B complex, C, and E does not appear to improve measles vaccine responses for HIV-exposed infants. Studies are needed to better characterize the impact of maternal HIV disease severity on the immune system development of HIV-exposed infants and the effect of malnutrition interventions on vaccine responses. (This study has been registered at ClinicalTrials.gov under registration no. NCT00197730.) Copyright © 2013, American Society for Microbiology.
Authors & Co-Authors
Sudfeld, Christopher Robert
United States, Boston
Harvard T.h. Chan School of Public Health
Duggan, Christopher P.
United States, Boston
Harvard T.h. Chan School of Public Health
United States, Boston
Boston Children's Hospital
Histed, Alex
United States, Boston
Jean Mayer Usda Human Nutrition Research Center on Aging
Manji, Karim Premji
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Meydani, S. N.
United States, Boston
Jean Mayer Usda Human Nutrition Research Center on Aging
United States, Medford
Tufts University
Aboud, Said
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Wang, Molin
United States, Boston
Harvard T.h. Chan School of Public Health
Giovannucci, Edward Luciano
United States, Boston
Harvard T.h. Chan School of Public Health
United States, Boston
Brigham and Women's Hospital
Fawzi, Wafaie W.
United States, Boston
Harvard T.h. Chan School of Public Health
Statistics
Citations: 9
Authors: 9
Affiliations: 6
Identifiers
Doi:
10.1128/CVI.00183-13
ISSN:
15566811
e-ISSN:
1556679X
Research Areas
Food Security
Infectious Diseases
Maternal And Child Health
Study Locations
Tanzania