Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Free leptin index and PAPP-A: A first trimester maternal serum screening test for pre-eclampsia
Prenatal Diagnosis, Volume 30, No. 2, Year 2010
Notification
URL copied to clipboard!
Description
Background: Prophylaxis with low-dose aspirin may reduce the risk of pre-eclampsia (PE) if introduced in first trimester. The performance of first trimester maternal serum screening for PE using free leptin index (fLI) and PAPP-A, where fLI = leptin/leptin soluble receptor was studied. Methods: First trimester serum samples from 126 PE pregnancies and 289 control pregnancies were studied. fLI and PAPP-A were converted into gestational age and maternal weight independent log MoM values of PAPP-A and fLI. The screening performance of markers was studied by receiver-operator-characteristics curves. The performance of population screening was estimated by Monte Carlo simulation. Results: fLI was significantly (p < 0.001) elevated [mean log MoM 0.2165 (SD: 0.2604)] compared to controls [mean log MoM -0.0368 (SD: 0.3132)] and PAPP-A was significantly (p < 0.001) reduced [mean log MoM -0.0133 (SD: 0.2661)] compared to controls [mean log MoM 0.0474 (SD: 0.2521)] in PE pregnancies. There was no correlation between fLI and PAPP-A in control or PE pregnancies. Combined fLI and PAPP-A screening for PE had estimated population detection rates of 22% and 35% for false positives rates of 6% and 12%, respectively. Conclusion: Combining PAPP-A and fLI improves screening performance for PE compared to single marker screening. Copyright © 2009 John Wiley & Sons, Ltd.
Authors & Co-Authors
Hedley, P. L.
Denmark, Copenhagen
Statens Serum Institut
South Africa, Stellenbosch
Stellenbosch University
Placing, Sophie
Denmark, Copenhagen
Statens Serum Institut
Wøjdemann, Karen Reinhold
Denmark, Copenhagen
Rigshospitalet
Carlsen, Anting L.
Denmark, Copenhagen
Statens Serum Institut
Shalmi, Anne Cathrine
Denmark, Copenhagen
Rigshospitalet
Sundberg, Karin M.
Denmark, Copenhagen
Rigshospitalet
Tabor, Ann
Denmark, Copenhagen
Rigshospitalet
Christiansen, Michael
Denmark, Copenhagen
Statens Serum Institut
Statistics
Citations: 32
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1002/pd.2337
ISSN:
01973851
e-ISSN:
10970223
Research Areas
Maternal And Child Health
Study Design
Cross Sectional Study