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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Specific diagnosis and follow-up of HIV-1 group O infection: RES-O data; [Diagnostic spécifique et prise en charge des infections par un VIH-1 groupe O: données de RES-O]
Medecine et Maladies Infectieuses, Volume 40, No. 12, Year 2010
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Description
Introduction: HIV-1 group O (HIV-O), mainly found in Cameroon, has a very high genetic diversity with consequences on the diagnosis and treatment of patients, requiring the development of specific tools. Objective: We present the currently available tools for the specific detection of HIV-O and its therapeutic monitoring, and the first RES-O data, a French network for the identification and monitoring of patients infected by HIV-O. Method: The diagnosis of infection was confirmed by group-specific envelope serotyping. The viral load was assessed by a specific technique, LTR-O, developed in the laboratory and compared to the nonspecific kit RealTime HIV-1 (Abbott). The sequencing of antiretroviral target regions (Protease, Reverse Transcriptase (RT), Integrase and Gp41), was performed by specific primers. The analysis of resistance mutations was performed with the ANRS algorithm used for HIV-M. Results: HIV-O infection was confirmed for 117 patients. Measuring viral load showed the two techniques were equivalent, but with a tendency to under-quantification for the Abbott technique greater than 1 log for 5% of samples. 70 to 100% of the studied strains had at least 10 mutations in the Protease, four4 in the RT, and one in Gp41, resulting in a natural genotypic resistance to some anti-retroviral molecules. Discussion: The diagnosis and monitoring of HIV-O infection is now possible. However, the impact of this variant's natural polymorphism on response to treatment remains undocumented. © 2010 Elsevier Masson SAS.
Authors & Co-Authors
Depatureaux, Agnès Geremy
France, Caen
Gram 2.0 - Groupe de Recherche Sur L'adaptation Microbienne
Leoz, Marie
France, Caen
Gram 2.0 - Groupe de Recherche Sur L'adaptation Microbienne
de Oliveira, Fabienne
France, Caen
Gram 2.0 - Groupe de Recherche Sur L'adaptation Microbienne
Gueudin, Marie
France, Caen
Gram 2.0 - Groupe de Recherche Sur L'adaptation Microbienne
Damond, Florence
France, Paris
Hôpital Bichat-claude-bernard Ap-hp
Descamps, Diáne
France, Paris
Hôpital Bichat-claude-bernard Ap-hp
Brun-Vézinet, Françoise
France, Paris
Hôpital Bichat-claude-bernard Ap-hp
Lémée, Véronique
France, Caen
Gram 2.0 - Groupe de Recherche Sur L'adaptation Microbienne
Simon, Franćois
France, Paris
Inserm
Barin, Françis
France, Tours
Centre Hospitalier Regional et Universitaire de Tours
Plantier, Jean Christophe
France, Caen
Gram 2.0 - Groupe de Recherche Sur L'adaptation Microbienne
Statistics
Citations: 20
Authors: 11
Affiliations: 4
Identifiers
Doi:
10.1016/j.medmal.2010.04.011
ISSN:
0399077X
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cohort Study
Study Locations
Cameroon