Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Morbidity and mortality among a cohort of human immunodeficiency virus type 1-infected and uninfected pregnant women and their infants from Malawi, Zambia, and Tanzania
Pediatric Infectious Disease Journal, Volume 27, No. 9, Year 2008
Notification
URL copied to clipboard!
Description
Background: Morbidity and mortality patterns among pregnant women and their infants (before antiretroviral therapy was widely available) determines HIV-1 diagnostic, monitoring, and care interventions. Methods: Data from mothers and their infants enrolled in a trial of antibiotics to reduce mother-to-child- transmission of HIV-1 at 4 sub-Saharan African sites were analyzed. Women were enrolled during pregnancy and follow-up continued until the infants reached 12 months of age. We describe maternal and infant morbidity and mortality in a cohort of HIV-1-infected and HIV-1-uninfected mothers. Maternal and infant factors associated with mortality risk in the infants were assessed using Cox proportional hazard modeling. Results: Among 2292 HIV-1-infected mothers, 166 (7.2%) had a serious adverse event (SAE) and 42 (1.8%) died, whereas no deaths occurred among the 331 HIV-1 uninfected mothers. Four hundred twenty-four (17.8%) of 2383 infants had an SAE and 349 (16.4%) died before the end of follow-up. Infants with early HIV-1 infection (birth to 4-6 weeks) had the highest mortality. Among infants born to HIV-1-infected women, maternal morbidity and mortality (P = 0.0001), baseline CD4 count (P = 0.0002), and baseline plasma HIV-1 RNA concentration (P < 0.0001) were significant predictors of infant mortality in multivariate analyses. Conclusions: The high mortality among infants with early HIV-1 infection supports access to HIV-1 diagnostics and appropriate early treatment for all infants of HIV-1-infected mothers. The significant association between stage of maternal HIV-1 infection and infant mortality supports routine CD4 counts at the time of prenatal HIV-1 testing. Copyright © 2008 by Lippincott Williams & Wilkins.
Authors & Co-Authors
Chilongozi, David A.T.
Malawi, Lilongwe
Unc Project-malawi
Wang, Lei
United States, Seattle
Fred Hutchinson Cancer Research Center
Brown, Lillian B.
United States, Raleigh
The University of North Carolina System
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Taha, Taha E.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Valentine, Megan E.
United States, Durham
Fhi 360
Emel, Lynda Marie
United States, Seattle
Fred Hutchinson Cancer Research Center
Sinkala, Moses M.
Zambia, Lusaka
Centre for Infectious Disease Research in Zambia
United States, Birmingham
The University of Alabama at Birmingham
Kafulafula, George
Malawi, Zomba
University of Malawi
Noor, Ramadhani Abdallah
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Read, Jennifer Suzanne
United States, Bethesda
National Institute of Child Health and Human Development Nichd
Brown, Elizabeth R.
United States, Seattle
University of Washington
Goldenberg, Robert L.
United States, Birmingham
The University of Alabama at Birmingham
Hoffman, Irving F.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Statistics
Citations: 92
Authors: 13
Affiliations: 12
Identifiers
Doi:
10.1097/INF.0b013e31817109a4
ISSN:
08913668
e-ISSN:
15320987
Research Areas
Environmental
Health System And Policy
Infectious Diseases
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Cohort Study
Study Locations
Malawi
Tanzania
Zambia
Participants Gender
Female