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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Epidemiology of rotavirus diarrhea among children younger than 5 years in Enugu, south east, Nigeria
Pediatric Infectious Disease Journal, Volume 33, No. SUPPL. 1, Year 2014
Notification
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Description
BACKGROUND:: Severe rotavirus diarrhea in children is a major cause of morbidity globally and mortality in developing countries. It is estimated to be responsible for >453,000 deaths in children <5 years of age globally and 232,000 in the African region. The aim of the current study was to determine the prevalence of rotavirus gastroenteritis among hospitalized children <5 years of age in Enugu and to support awareness and advocacy efforts for the introduction of rotavirus vaccines in Nigeria. METHODS:: World Health Organization-standardized case forms were used to collect data from eligible children with non-bloody diarrhea from October 2010 to September 2012. Data collected included socio-demographic and clinical information. Stool samples were obtained from recruited children and tested for rotavirus antigen using the Oxoid Prospect ELISA Kit (Basingstoke, United Kingdom). RESULTS:: Of the 615 diarrhea stool samples collected, 344 (56%) were positive for human rotavirus. Of the 344 positive samples, 329 (96%) were children <2 years of age, while 247 (77%) were <1 year of age. Peak rotavirus season occurred during the cold dry months of December to April during which 95% of all cases occurred. CONCLUSIONS:: This study found a relatively high incidence of severe rotavirus-associated diarrhea disease in Nigeria and infants were the most affected. It highlights the urgent need for introduction of rotavirus vaccine into the national immunization program and the need to adequately equip health facilities to enable them administer intravenous fluids to severe diarrhea patients to reduce morbidity and mortality. © 2013 Lippincott Williams and Wilkins.
Authors & Co-Authors
Tagbo, Beckie Nnenna
Nigeria, Naukka
University of Nigeria
Mwenda, Jason Mathiu
Switzerland, Geneva
Organisation Mondiale de la Santé
Armah, George Enyimah
Ghana, Accra
University of Ghana
Obidike, Egbuna O.
Unknown Affiliation
Okafor, Uche H.
Nigeria, Naukka
University of Nigeria
Oguonu, Tagbo A.
Unknown Affiliation
Ozumba, U. C.
Nigeria, Naukka
University of Nigeria
Eke, Christopher Bismarck
Unknown Affiliation
Chukwubuike, C.
Nigeria, Naukka
University of Nigeria
Edelu, Benedict Onyeka
Unknown Affiliation
Ezeonwu, Bertilla Uzoma
Unknown Affiliation
Amadi, Oge
Unknown Affiliation
Okeke, Ifeyinwa Bernadette
Unknown Affiliation
Nnani, Okechukwu R.
Nigeria, Naukka
University of Nigeria
Ani, Okechukwu
Unknown Affiliation
Ugwuezeonu, Ikechukwu
Nigeria, Enugu
Mother of Christ Specialist Hospital
Benjamin-Pujah, C.
Nigeria, Naukka
University of Nigeria
Umezinne, N.
Nigeria, Naukka
University of Nigeria
Ude, Nelson
Nigeria, Naukka
Enugu State University Teaching Hospital
Nwodo, Chimezie
Nigeria, Naukka
Enugu State University Teaching Hospital
Ezeonyebuchi, M. C.
Nigeria, Enugu
Mother of Christ Specialist Hospital
Umesie, Esther
Nigeria, Naukka
University of Nigeria
Okafor, V.
Nigeria, Naukka
University of Nigeria
Ogude, N.
Nigeria, Naukka
University of Nigeria
Osarogborum, Vivian O.
Nigeria, Naukka
University of Nigeria
Ezebilo, S. K.
Nigeria, Naukka
University of Nigeria
Goitom, Weldegebriel G.
Switzerland, Geneva
Organisation Mondiale de la Santé
Abanida, Emmanuel Ade
Nigeria, Abuja
Federal Ministry of Health
Elemuwa, Chris O.
Nigeria, Abuja
Federal Ministry of Health
Nwagbo, Douglas F.E.
Nigeria, Exeter
University of
Statistics
Citations: 32
Authors: 30
Affiliations: 7
Identifiers
Doi:
10.1097/INF.0000000000000047
ISSN:
08913668
e-ISSN:
15320987
Research Areas
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Nigeria