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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Depressive symptoms increase risk of HIV disease progression and mortality among women in Tanzania
Journal of Acquired Immune Deficiency Syndromes, Volume 44, No. 4, Year 2007
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Description
The effect of depression on HIV disease progression was examined among 996 HIV-positive Tanzanian women participating in a trial on micronutrients and pregnancy outcomes, vertical transmission, and disease progression. Depression and social support were measured 2 months after HIV screening and every 6 to 12 months thereafter. Depression measures from pregnancy and more than 12 months postpartum were included in this analysis. Participants' clinical condition and access to supportive individual or group counseling was assessed throughout the 6 to 8 years of follow-up. Cox proportional hazard models were used to estimate the time-varying effect of depression on progression to HIV clinical stage III/IV (World Health Organization) and all-cause mortality. Participation in group or individual counseling and baseline social support were also examined. More than half (57%) of the study sample had symptoms comparable with depression at least once during the follow-up period. Controlling for sociodemographic variables, psychosocial support, and clinical condition at enrollment, depression was associated with an increased risk of disease progression (HIV clinical stage III/IV [hazard ratio (HR) = 1.61, 95% confidence interval (CI): 1.28 to 2.03] and mortality [HR = 2.65, 95% CI: 1.89 to 3.71]). Depression is common among HIV-infected Tanzanian women and increases the risk of disease progression. Screening for depression and providing psychosocial interventions should be considered part of comprehensive HIV care. © 2007 Lippincott Williams & Wilkins, Inc.
Authors & Co-Authors
Antelman, Gretchen
United States, Boston
Harvard T.h. Chan School of Public Health
Kaaya, Sylvia F.
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Wei, Ruilan
United States, Boston
Harvard T.h. Chan School of Public Health
Mbwambo, Jessie Kazeni Kilonzo
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Msamanga, Gernard I.
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Fawzi, Wafaie W.
United States, Boston
Harvard T.h. Chan School of Public Health
Smith-Fawzi, Mary Catherine
United States, Boston
Harvard Medical School
Statistics
Citations: 251
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1097/QAI.0b013e31802f1318
ISSN:
15254135
Research Areas
Environmental
Health System And Policy
Infectious Diseases
Maternal And Child Health
Mental Health
Sexual And Reproductive Health
Study Design
Cohort Study
Study Locations
Tanzania
Participants Gender
Female