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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Early atopic disease and early childhood immunization - Is there a link?
Allergy: European Journal of Allergy and Clinical Immunology, Volume 63, No. 11, Year 2008
Notification
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Description
Background: There are frequent concerns about early immunizations among the parents of children at heightened risk for atopy. The study assessed the effect of vaccine immunization before the first birthday on eczema severity and allergic sensitization in the second year of life. Methods: A total of 2184 infants, aged 1-2 years, with established atopic dermatitis and a family history of allergy, from 97 study centres in 10 European countries, South Africa and Australia were included. Exposure to vaccines (diphtheria, tetanus, pertussis, polio, Haemophilus influenzae Type B, hepatitis B, mumps, measles, rubella, varicella, BCG, meningococci and pneumococci) and immunization dates were recorded from immunization cards. Immunoglobulin E (IgE) was determined by RAST and eczema severity was assessed by scoring atopic dermatitis (SCORAD). Results: Immunization against any target was not associated with an increased risk of allergic sensitization to food or inhalant allergens. Varicella immunization (only 0.7% immunized) was inversely associated with total IgE > 30 kU/l (OR 0.27; 95% CI 0.08-0.87) and eczema severity (OR 0.34; 95% CI 0.12-0.93). Pertussis immunization (only 1.7% nonimmunized) was inversely associated with eczema severity (OR 0.30; 95% CI 0.10-0.89). Cumulative received vaccine doses were inversely associated with eczema severity (P = 0.0107). The immunization coverage of infants before and after the onset of atopic dermatitis was similar. Conclusion: In children at heightened risk for atopy, common childhood immunization in the first year is not associated with an increased risk of more severe eczema or allergic sensitization. Parents of atopic children should be encouraged to fully immunize their children. © 2008 The Authors.
Authors & Co-Authors
Warner, John Oliver
United Kingdom, London
Imperial College London
Naspitz, Charles Kirov
Unknown Affiliation
Simons, F. E.R.
Unknown Affiliation
Diepgen, Thomas Ludwig
Unknown Affiliation
Wahn, Ulrich
Unknown Affiliation
von Mutius, Erika R.M.
Unknown Affiliation
Gold, Michael Steven
Unknown Affiliation
Marshall, Helen Siobhan
Unknown Affiliation
Sly, Peter D.
Unknown Affiliation
Loh, Richard K.S.
Unknown Affiliation
Halbert, Anne R.
Unknown Affiliation
Stick, S. M.
Unknown Affiliation
van Asperen, Peter Paul
Unknown Affiliation
Škopková, Olga
Unknown Affiliation
Petrů, Vít
Unknown Affiliation
Pohunek, Petr
Unknown Affiliation
Cambazard, Frederique É.
Unknown Affiliation
Rancé, Fabienne
Unknown Affiliation
Niggemann, Bodo
Unknown Affiliation
Schauer, Uwe
Unknown Affiliation
Hertl, Michael S.
Unknown Affiliation
Ring, Johannes
Unknown Affiliation
von Berg, Andrea
Unknown Affiliation
Albrecht, Beate
Unknown Affiliation
Duse, Marzia
Unknown Affiliation
Fiocchi, Alessandro Giovanni
Unknown Affiliation
Terracciano, L. Maria
Unknown Affiliation
Marseglia, Gian Luigi
Unknown Affiliation
Tzialla, Chryssoula
Unknown Affiliation
Galli, E.
Unknown Affiliation
Rossi, Paolo
Unknown Affiliation
Moschese, Viviana
Unknown Affiliation
Boner, Attillio Loris
Unknown Affiliation
Oranje, Arnold P.
Unknown Affiliation
Pasmans, S. G.M.A.
Unknown Affiliation
Lis, Grzegorz J.
Unknown Affiliation
Emeryk, Andrzej
Unknown Affiliation
Brȩborowicz, Anna
Unknown Affiliation
Kulus, Marek Krzysztof
Unknown Affiliation
Boznánski, Andrzej
Unknown Affiliation
Asensio-De-La-Cruz, Òscar
Unknown Affiliation
Nieto García, Antonio
Unknown Affiliation
Puterman, Allan S.
Unknown Affiliation
Vermeulen, Jan H.
Unknown Affiliation
Suleman, Moosa
Unknown Affiliation
Potter, Paul C.
Unknown Affiliation
Hawarden, D.
Unknown Affiliation
Motala, Cassim M.
Unknown Affiliation
Weber, Heinrich C.
Unknown Affiliation
Reyneke, S. J.
Unknown Affiliation
Morison, Adrian
Unknown Affiliation
Arshad, Syed Hasan
Unknown Affiliation
Roberts, Graham C.
Unknown Affiliation
Hourihane, Jonathan O.Brien
Unknown Affiliation
Roberts, Graham C.
Unknown Affiliation
Statistics
Citations: 49
Authors: 55
Affiliations: 5
Identifiers
Doi:
10.1111/j.1398-9995.2008.01696.x
ISSN:
13989995
Research Areas
Food Security
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Locations
South Africa