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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The bioavailability of vitamin D from fortified cheeses and supplements is equivalent in adults
Journal of Nutrition, Volume 138, No. 7, Year 2008
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Description
There is a need to increase the options for vitamin D fortification. We have developed a method to fortify hard cheese with vitamin D. Our aim was to characterize the bioavailability of vitamin D from fortified cheeses. Eighty adults were randomized to weekly servings of fortified cheddar cheese (DC) (34 g; n = 20); fortified low-fat cheese (DLF) (41 g; n = 10); liquid vitamin D supplement (1 mL), taken with food (DS+) (n = 20) or without food (DS-) (n = 10); placebo cheddar cheese (n = 10); or placebo supplement (n = 10). The treatments contained 28,000 IU cholecalcifero! (vitamin D3), equivalent to 4000 IU (100 μg/d). The primary outcome was the comparison of vitamin D bioavailability, as measured by the serum 25-hydroxyvitamin D [25(OH)D] response, between fortified cheeses and supplement. In the placebo groups, initial 25(OH)D, 55.0 ± 25.3 nmol/L, declined over the 8-wk winter protocol, to 50.7 ± 24.2 nmol/L (P = 0.046). In the vitamin D-treated groups, the mean increases in 25(OH)D over 8 wk were: 65.3 ± 24.1 (DC), 69.4 ± 21.7 (DLF), 59.3 ± 23.3 (DS+), and 59.3 ±19.6 nmol/L (DS-); these changes differed from the placebo groups (P< 0.0001) but not from one another (P= 0.62). Compared with baseline, serum parathyroid hormone decreased with both fortification (P= 0.003) and supplementation (P= 0.012). These data demonstrate that vitamin D is equally bioavailable from fortified hard cheeses and supplements, making cheese suitable for vitamin D fortification. © 2008 American Society for Nutrition.
Authors & Co-Authors
Wagner, Dennis
Canada, Toronto
University of Toronto
Canada, Toronto
Mount Sinai Hospital of University of Toronto
Sidhom, Gloria G.
Egypt, Giza
National Research Centre
Whiting, Susan Joyce
Canada, Saskatoon
University of Saskatchewan
Rousseau, Dérick
Canada, Toronto
Toronto Metropolitan University
Vieth, Reinhold
Canada, Toronto
University of Toronto
Canada, Toronto
Mount Sinai Hospital of University of Toronto
Statistics
Citations: 97
Authors: 5
Affiliations: 5
Identifiers
Doi:
10.1093/jn/138.7.1365
ISSN:
00223166
Research Areas
Food Security