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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Kinetics of Circulating Human IgG4 after Diethylcarbamazine and Ivermectin Treatment of Bancroftian Filariasis
Journal of Infectious Diseases, Volume 165, No. 6, Year 1992
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Description
Patent filarial infections are associated with elevated levels of parasite-specific IgG4. This study investigated the shifts of filarial-specific human IgG and IgG4 antibodies after diethylcarbamazine and ivermectin treatment of bancroftian filariasis. Thirty adult Haitians were treated first with a 1-mg clearing dose of ivermectin and then with either one or two 200-µg/kg doses of ivermectin or with 12 daily 6-mg/kg doses of diethylcarbamazine. Posttreatment levels of antifi- larial IgG4 were dependent on both treatment group and time of follow-up. IgG4 increased markedly to a maximum by day 30 in all treatment groups and then began to decrease; the greatest decrease was among diethylcarbamazine-treated patients. Posttreatment microfilaremia was inversely correlated with the decrease in IgG4; thus, shifts in IgG4 were associated with treatment response for all groups. Antifilarial IgG levels were not correlated with drug treatment and did not change to the same degree as did IgG4 responses. © 1992 The University of Chicago.
Authors & Co-Authors
Njeri Wamae, C.
United States, New Orleans
Tulane University
Kenya, Nairobi
Kenya Medical Research Institute
United States, Atlanta
National Center for Infectious Diseases
Roberts, Jacquelin M.
United States, New Orleans
Tulane University
Kenya, Nairobi
Kenya Medical Research Institute
United States, Atlanta
National Center for Infectious Diseases
Eberhard, Mark L.
United States, New Orleans
Tulane University
Kenya, Nairobi
Kenya Medical Research Institute
United States, Atlanta
National Center for Infectious Diseases
Lammie, Patrick J.
United States, New Orleans
Tulane University
Kenya, Nairobi
Kenya Medical Research Institute
United States, Atlanta
National Center for Infectious Diseases
Statistics
Citations: 35
Authors: 4
Affiliations: 3
Identifiers
Doi:
10.1093/infdis/165.6.1158
ISSN:
00221899
e-ISSN:
15376613
Study Design
Cohort Study