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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Bioactive diterpenes from Orthosiphon labiatus and Salvia africana-lutea
Journal of Natural Products, Volume 70, No. 2, Year 2007
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Description
The known (+)-trans-ozic acid (1) and two new labdane diterpenoids (2 and 3) have been isolated from an ethanol extract of Orthosiphon labiatus. The structures of 2 and 3 were established mainly by 1D and 2D NMR spectroscopic means. The ethanolic extract of Salvia africana-lutea afforded the known abietane diterpenoids carnosol (4), rosmadial (5), and carnosic acid (characterized as its derivative 6). Compounds 3 and 6 exhibited MICs of 157 and 28 μM, respectively, against Mycobacterium tuberculosis, while 2 and 6 showed cytotoxic activity with IC50 82 and 69 μM, respectively, against a breast (MCF-7) human cancer cell line. © 2007 American Chemical Society and American Society of Pharmacognosy.
Authors & Co-Authors
Hussein, Ahmed Abdel Fattah
Egypt, Giza
National Research Centre
Meyer, Jacobus Johannes Marion
South Africa, Pretoria
University of Pretoria
Luisa Jimeno, María
Spain, Madrid
Csic - Centro de Quimica Organica Lora Tamayo Cenquior
Rodrı́guez, Benjamı́n
Spain, Madrid
Csic - Instituto de Química Orgánica General Iqog
Statistics
Citations: 73
Authors: 4
Affiliations: 4
Identifiers
Doi:
10.1021/np0680376
ISSN:
01633864
Research Areas
Cancer