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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Extracellular volume fraction is more closely associated with altered regional left ventricular velocities than left ventricular ejection fraction in nonischemic cardiomyopathy
Circulation: Cardiovascular Imaging, Volume 8, No. 1, Article e001998, Year 2014
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Description
Background: Nonischemic cardiomyopathy is a common cause of left ventricular (LV) dysfunction and myocardial fibrosis. The purpose of this study was to noninvasively evaluate changes in segmental LV extracellular volume (ECV) fraction, LV velocities, myocardial scar, and wall motion in nonischemic cardiomyopathy patients. Methods and Results: Cardiac MRI including pre- and postcontrast myocardial T1 mapping and velocity quantification (tissue phase mapping) of the LV (basal, midventricular, and apical short axis) was applied in 31 patients with nonischemic cardiomyopathy (50±18 years). Analysis based on the 16-segment American Heart Association model was used to evaluate the segmental distribution of ECV, peak systolic and diastolic myocardial velocities, scar determined by late gadolinium enhancement, and wall motion abnormalities. LV segments with scar or impaired wall motion were significantly associated with elevated ECV (rs =0.26; P<0.001) and reduced peak systolic radial velocities (r=-0.43; P<0.001). Regional myocardial velocities and ECV were similar for patients with reduced (n=12; ECV=0.28±0.06) and preserved left ventricular ejection fraction (n=19; ECV=0.30±0.09). Patients with preserved left ventricular ejection fraction showed significant relationships between increasing ECV and reduced systolic (r=-0.19; r=-0.30) and diastolic (r=0.34; r=0.26) radial and long-axis peak velocities (P<0.001). Even after excluding myocardial segments with late gadolinium enhancement, significant relationships between ECV and segmental LV velocities were maintained indicating the potential of elevated ECV to identify regional diffuse fibrosis not visible by late gadolinium enhancement, which was associated with impaired regional LV function. Conclusions: Regionally elevated ECV negatively affected myocardial velocities. The association of elevated regional ECV with reduced myocardial velocities independent of left ventricular ejection fraction suggests a structure-function relationship between altered ECV and segmental myocardial function in nonischemic cardiomyopathy. © 2014 American Heart Association, Inc.
Authors & Co-Authors
Spottiswoode, Bruce S.
United States, New York
Siemens Usa
Benzuly, Keith H.
United States, Chicago
Northwestern University Feinberg School of Medicine
Lee, Daniel C.
United States, Chicago
Northwestern University Feinberg School of Medicine
Yancy, Clyde W.
United States, Chicago
Northwestern University Feinberg School of Medicine
Carr, James C.
United States, Evanston
Northwestern University
Markl, Michael
United States, Evanston
Northwestern University
United States, Chicago
Northwestern University Feinberg School of Medicine
Statistics
Citations: 13
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1161/CIRCIMAGING.114.001998
ISSN:
19419651
Research Areas
Noncommunicable Diseases