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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
chemistry
Synthesis of novel guttiferone A derivatives: In-vitro evaluation toward Plasmodium falciparum, Trypanosoma brucei and Leishmania donovani
European Journal of Medicinal Chemistry, Volume 65, Year 2013
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Description
The catechol pharmacomodulation of the natural product guttiferone A, isolated from the Symphonia globulifera tree, led to the semisynthesis of a collection of twenty derivatives. The ester and ether derivatives of guttiferone A were evaluated for their anti-plasmodial, trypanocidal and anti-leishmanial activities. Some compounds described below have shown potent antiparasitic activity against Plasmodium falciparum, Trypanosoma brucei and Leishmania donovani in a range from 1 to 5 μM. The evaluation of guttiferone A derivatives against VERO cells highlighted catechol modulations as an interesting tool to decrease the toxicity and keep the activity of this natural compound. The current study revealed new molecules as promising new antiparasitic drug candidates. © 2013 Elsevier Masson SAS. All rights reserved.
Authors & Co-Authors
Fromentin, Yann
France, Paris
Cibles Thérapeutiques et Conception de Médicaments
Gaboriaud-Kolar, Nicolas
France, Paris
Cibles Thérapeutiques et Conception de Médicaments
Lenta, Bruno Ndjakou
Cameroon, Yaounde
Université de Yaoundé I
Wansi, Jean Duplex
Cameroon, Douala
University of Douala
Buisson, Didier
France, Paris
Museum National D'histoire Naturelle
Mouray, Elisabeth
France, Paris
Museum National D'histoire Naturelle
Gréllier, Philippe
France, Paris
Museum National D'histoire Naturelle
Loiseau, Philippe Marie
France, Paris
Cnrs Centre National de la Recherche Scientifique
Lallemand, Marie Christine
France, Paris
Cibles Thérapeutiques et Conception de Médicaments
Michel, Sylvie
France, Paris
Cibles Thérapeutiques et Conception de Médicaments
Statistics
Citations: 26
Authors: 10
Affiliations: 5
Identifiers
Doi:
10.1016/j.ejmech.2013.04.066
ISSN:
02235234
e-ISSN:
17683254