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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Hsp-72, a candidate prognostic indicator of heatstroke
Cell Stress and Chaperones, Volume 15, No. 5, Year 2010
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Description
Exposure of rats to environmental heat enhances the expression of heat shock protein-72 (Hsp-72) in most of their organs proportionally to heat stress severity. Pre-induction or over-expression of Hsp-72 prevents organ damage and lethality, suggesting that heat shock proteins (Hsps) may have a pathogenic role in this condition. We investigated the expression profile of Hsps in baboons subjected to environmental heat stress until the core temperature attained 42.5°C (moderate heatstroke) or occurrence of hypotension associated with core temperature ≥ 43.5°C (severe heatstroke). Western blot analysis demonstrated a differential induction of Hsp-72 among organs of heat-stressed animals with the highest induction in the liver and the lowest in lung. Hsp-60 and Hsc-70 expression was similar between control and heat-stressed animals. ELISA studies indicated a marked release of Hsp-72 into the circulation of baboons with severe heatstroke with a peak at 24 h post-heatstroke onset and remained sustained up to 72 h. Hsp-72 release was not associated with core temperature or systolic blood pressure, but correlated with markers of liver, myocardium, and skeletal muscle tissue necrosis. Non-survivors displayed significantly higher Hsp-72 levels than survivors. No Hsp-60 was detected in the circulation. These findings add further evidence that increased expression of Hsp-72 may be an important component of the host response to severe heatstroke. They also suggest that extracellular Hsp-72 is a marker of multiple organs tissue damage. Whether extracellular Hsp-72 plays a role in the host immune response to heat stress merits further studies. © 2010 Cell Stress Society International.
Authors & Co-Authors
Dehbi, Mohammed
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Kuwait, Dasman
Dasman Diabetes Institute
Baturcam, Engin
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
ElDali, Abdelmoneim M.
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Ahmed, Maqbool
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Kwaasi, Aaron A.A.
United Kingdom, Oxford
University of Oxford
Chishti, Muhammad Azhar
Saudi Arabia, Riyadh
College of Medicine
Bouchama, A.
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Statistics
Citations: 41
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1007/s12192-010-0172-3
ISSN:
13558145
e-ISSN:
14661268
Research Areas
Noncommunicable Diseases