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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Development of multiple drug resistance of Trypanosoma congolense in Zebu cattle under high natural tsetse fly challenge in the pastoral zone of Samorogouan, Burkina Faso
Acta Tropica, Volume 51, No. 3-4, Year 1992
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Description
Preliminary data from an ongoing epidemiological survey in the pastoral zone of Samorogouan (Kénédougou) indicate the occurrence of multiple-drug-resistant Trypanosoma congolense. Despite frequent trypanocidal drug treatments with diminazene aceturate (Berenil®, Hoechst) at 7 mg/kg body weight (bw) at intervals of 2 to 4 weeks, no significant drop in the prevalence of African animal trypanosomosis (AAT) was observed. To examine a suspected drug resistance, 20 Zebu cattle, naturally infected with T. congolense and/or T. vivax, were transferred in December 1989 from Samorogouan into a fly-proof stable. Diminazene aceturate at 7 mg/kg bw cured infections of T. vivax, but was ineffective against T. congolense. Likewise, treatments with homidium bromide (Ethidium®, FBC) at 1 mg/kg bw and isometamidium chloride (Trypamidium®, Rhône Mérieux) at 1 mg/kg bw, respectively, proved to be ineffective. Corresponding chemotherapeutic trials in previously unexposed Zebu bulls and Sahelian goats infected with one primary T. congolense isolate from Samorogouan demonstrated a high level of resistance to diminazene aceturate (7 mg/kg bw in cattle and 17.5 mg/kg bw in goats), isometamidium chloride (1 and 2 mg/kg bw i.v. in goats) and quinapyramine sulphate (Trypacide'S'®, Rhône Mérieux) at 5 mg/kg bw in goats. The appearance of a multiple-drug-resistant strain of T. congolense emphasizes the urgent need for new chemical substances as trypanocidal drugs and the increasing importance of efficient vector control. © 1992.
Authors & Co-Authors
Clausen, Peter Henning
Burkina Faso
Centre de Recherches Sur Les Trypanosomoses Animales Crta
Sidibé, Issa
Burkina Faso
Centre de Recherches Sur Les Trypanosomoses Animales Crta
Kaboré, Idrissa
Burkina Faso
Centre de Recherches Sur Les Trypanosomoses Animales Crta
Bauer, Burkhard
Burkina Faso
Centre de Recherches Sur Les Trypanosomoses Animales Crta
Statistics
Citations: 78
Authors: 4
Affiliations: 1
Identifiers
Doi:
10.1016/0001-706X(92)90041-U
ISSN:
0001706X
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
Burkina Faso