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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
International eDelphi Study to Reach Consensus on the Methotrexate Dosing Regimen in Patients With Psoriasis
JAMA Dermatology, Volume 158, No. 5, Year 2022
Notification
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Description
Importance: A clear dosing regimen for methotrexate in psoriasis is lacking, and this might lead to a suboptimal treatment. Because methotrexate is affordable and globally available, a uniform dosing regimen could potentially optimize the treatment of patients with psoriasis worldwide. Objective: To reach international consensus among psoriasis experts on a uniform dosing regimen for treatment with methotrexate in adult and pediatric patients with psoriasis and identify potential future research topics. Design, Setting, and Participants: Between September 2020 and March 2021, a survey study with a modified eDelphi procedure that was developed and distributed by the Amsterdam University Medical Center and completed by 180 participants worldwide (55 [30.6%] resided in non-Western countries) was conducted in 3 rounds. The proposals on which no consensus was reached were discussed in a conference meeting (June 2021). Participants voted on 21 proposals with a 9-point scale (1-3 disagree, 4-6 neither agree nor disagree, 7-9 agree) and were recruited through the Skin Inflammation and Psoriasis International Network and European Academy of Dermatology and Venereology in June 2020. Apart from being a dermatologist/dermatology resident, there were no specific criteria for participation in the survey. The participants worked mainly at a university hospital (97 [53.9%]) and were experienced in treating patients with psoriasis with methotrexate (163 [91.6%] had more than 10 years of experience). Main Outcomes and Measures: In a survey with eDelphi procedure, we tried to reach consensus on 21 proposals. Consensus was defined as less than 15% voting disagree (1-3). For the consensus meeting, consensus was defined as less than 30% voting disagree. Results: Of 251 participants, 180 (71.7%) completed all 3 survey rounds, and 58 participants (23.1%) joined the conference meeting. Consensus was achieved on 11 proposals in round 1, 3 proposals in round 2, and 2 proposals in round 3. In the consensus meeting, consensus was achieved on 4 proposals. More research is needed, especially for the proposals on folic acid and the dosing of methotrexate for treating subpopulations such as children and vulnerable patients. Conclusions and Relevance: In this eDelphi consensus study, consensus was reached on 20 of 21 proposals involving methotrexate dosing in patients with psoriasis. This consensus may potentially be used to harmonize the treatment with methotrexate in patients with psoriasis. © 2022 American Medical Association. All rights reserved.
Authors & Co-Authors
van Huizen, Astrid M.
Netherlands, Amsterdam
Amsterdam Public Health
Menting, Stef P.
Netherlands, Amsterdam
Olvg
Gyulai, Rolland
Hungary, Pecs
Pécsi Tudományegyetem
Iversen, Lars Fogh
Denmark, Aarhus
Aarhus Universitetshospital
van der Kraaij, Gayle E.
Netherlands, Amsterdam
Amsterdam Public Health
Middelkamp-Hup, Maritza Albertina
Netherlands, Amsterdam
Amsterdam Public Health
Warren, Richard B.
United Kingdom, Salford
Salford Royal Nhs Foundation Trust
Spuls, Phyllis Ira
Netherlands, Amsterdam
Amsterdam Public Health
Schejtman, Adrián A.
Argentina, Buenos Aires
Centro Dermatológico Schejtman
Egeberg, Alexander
Denmark, Copenhagen
Bispebjerg Hospital
Firooz, Alireza
Iran, Tehran
Tehran University of Medical Sciences
Kumar, Alur S.
India, Chennai
Apollo Hospitals Group
Oakley, Amanda M.M.
New Zealand, Hamilton
Waikato District Health Board
Foulkes, Amy Charlotte
United Kingdom, Salford
Salford Royal Nhs Foundation Trust
Ramos, Andréa Machado Coelho
Brazil, Belo Horizonte
Universidade Federal de Minas Gerais
Fougerousse, Anne Claire
France, Saint-mande
Hôpital D'instruction Des Armées Begin
Čarija, Antoanela
Croatia, Split
Klinički Bolnički Centar Split
Akman-Karakaş, Ayşe
Turkey, Antalya
Akdeniz Üniversitesi
Horváth, Barbara V.
Netherlands, Groningen
Rijksuniversiteit Groningen
Fábos, Béata
Hungary, Kaposvar
Teaching Hospital Kaposvar
Matlock, Benjamin Hidalgo
Costa Rica, San Jose
Hospital Nacional de Niños Dr. Carlos Sáenz Herrera
Claréus, Birgitta Wilson
Sweden, Stockholm
Psoriasis Treatment Wards
Castro, Carla
Argentina, Buenos Aires
Universidad Austral
Ferrándiz, Carlos
Spain, Cerdanyola Del Valles
Universitat Autònoma de Barcelona
Correa, Carolina Cortés
Colombia, Bogota
Dermatology Service of la Samaritana University Hospital
Colombia, Bogota
Universidad Nacional de Colombia
Marchesi, Carolina
Argentina, San Juan
Proderma
Goujon, Catherine
France, Lyon
Centre Hospitalier Lyon-sud
Gonzalez, Cesar
Colombia, Bogota
Dermatology Service of la Samaritana University Hospital
Maldonado-García, César Alfonso
Mexico, Mexico
Centro Dermatolgico de Dr. Ladislao de la Pascua
Hong, Chih Ho
Canada, Vancouver
The University of British Columbia
Griffiths, Christopher E. M.
United Kingdom, Salford
Salford Royal Nhs Foundation Trust
Vestergaard, Christian
Denmark, Aarhus
Aarhus Universitetshospital
Echeverría, Cristina Mariela
Argentina, Buenos Aires
Irep
de la Cruz, Claudia
Chile, Santiago
Clinica Dermacross
Conrad, C.
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Töröcsik, Dániel
Unknown Affiliation
Ledić-Drvar, Daniela
Croatia, Zagreb
University of Zagreb
Balak, Deepak Mw W.
Unknown Affiliation
Jullien, Dennis
France, Lyon
Chu de Lyon
Appelen, Diebrecht
Netherlands, Nijmegen
Radboud University Medical Center
Kim, Donghyun
South Korea, Pocheon
College of Medicine, Pochon Cha University
de Jong, Elke M.G.J.
Netherlands, Nijmegen
Radboud University Medical Center
El-Gamal, Emad Eldin Abdelmoneim
Egypt, Cairo
Faculty of Medicine
Laffitte, Emmanuel A.
Switzerland, Geneva
Hôpitaux Universitaires de Genève
Mahé, Emmanuel
France, Argenteuil
Centre Hospitalier Victor Dupouy D'argenteuil
Sonkoly, Eniko
Sweden, Uppsala
Uppsala Universitet
Colombo, Erika Páez
Venezuela, Caracas
Hospital Vargas de Caracas
Vilarrasa, Eva
Spain, Barcelona
Hospital de la Santa Creu I Sant Pau
Willaert, Fabienne
Belgium, Brussels
Université Libre de Bruxelles
Novoa, Farah D.
Unknown Affiliation
Handjani, Farhad
Iran, Shiraz
Shiraz University of Medical Sciences
Valenzuela, Fernando A.
Chile, Santiago
Universidad de Chile
Vílchez-Márquez, Francisco
Spain, Granada
Complejo Hospitalario Universitario de Granada
Gonzalez, Gabriela Otero
Uruguay, Montevideo
Hospital de Clinicas Dr. Manuel Quintela
Gáspár, Krisztián
Unknown Affiliation
Damiani, Giovanni
Italy, Milan
Irccs Istituto Ortopedico Galeazzi
Italy, Milan
Università Degli Studi Di Milano
Krnjević-Pezić, Gordana
Croatia, Zagreb
Special Hospital for Developmental Neurology and Rehabilitation
Pellerano, Graciela
Argentina
Soarpso
Carretero-Hernández, Gregorio
Spain, Las Palmas de Gran Canaria
Hospital de Gran Canaria Dr. Negrin
Hunter, Hamish J.A.
United Kingdom, Salford
Salford Royal Nhs Foundation Trust
Riad, Hassan
Qatar, Doha
Hamad Medical Corporation
Oon, Hazel H.
Singapore, Singapore City
National Skin Centre, Singapore
Boonen, Hugo P.J.
Belgium, Leuven
Heilig Hartziekenhuis
Moussa, Iftin Osman
Djibouti
Hôpital Cheiko
García-Doval, Ignacio
Spain, Vigo
Complejo Hospitalario Universitario de Vigo
Csányi, Ildíko
Hungary, Szeged
Szegedi Tudományegyetem Általános Orvostudományi Kar
Brajac, Inés
Croatia, Rijeka
Klinički Bolnički Centar Rijeka
Turchin, Irina
Canada, Fredericton
Brunswick Dermatology Center
Canada, Halifax
Dalhousie University
Canada, Waterloo
Probity Medical Research
Grozdev, Ivan S.
Belgium, Brussels
Centre Hospitalier Universitaire Brugmann, Brussels
Weinberg, Jeffrey M.
United States, New York
Icahn School of Medicine at Mount Sinai
Nicolopoulos, Jenny
Australia, Melbourne
Royal Melbourne Hospital
Wells, Jillian
Australia, Sydney
Westmead Hospital
Lambert, Jo Lydie Wilfried
Unknown Affiliation
Ingram, John Robert
United Kingdom, Cardiff
Cardiff University
Prinz, Jörg Christoph
Germany, Munich
Ludwig-maximilians-universität München
de Souza Sittart, José Alexandre
Brazil, Sao Paulo
Hospital do Servidor Publico Estadual
Sánchez, José Luis Alfonso
Spain, Valencia
Hospital General Universitario de Valencia
Hsiao, Josephine Pa Fan
Taiwan, Taipei
Mackay Memorial Hospital Taiwan
Castro-Ayarza, Juan Raúl
Colombia, Cajicá
Universidad Militar
Maul, Julia Tatjana
Switzerland, Zurich
Universitatsspital Zurich
van den Reek, Juul M.P.A.
Netherlands, Nijmegen
Radboud University Medical Center
Trčko, Katarina
Slovenia, Maribor
Univerzitetni Klinični Center Maribor
Barber, Kirk A.
Canada, Calgary
University of Calgary
Reich, Kristian
Germany, Hamburg
Universitätsklinikum Hamburg-eppendorf
Gebauer, Kurt Aaron
Australia, Fremantle
Fremantle Dermatology
Khobzei, Kuzma
Ukraine, Kyiv
Kyiv Medical University
Maul, Lara Valeska
Switzerland, Basel
Universitätsspital Basel
Prpić-Massari, Larisa
Croatia, Rijeka
Klinički Bolnički Centar Rijeka
Fardet, Laurence
France, Creteil
Hôpital Henri Mondor
Le Cleach, Laurence
France, Creteil
Université Paris-est Créteil Val de Marne
Misery, Laurent
France, Brest
Centre Hospitalier Universitaire de Brest
Chandrashekar, Laxmisha
India, Puducherry
Jawaharlal Institute of Postgraduate Medical Education and Research
Muresanu, Lidia Irinel
Romania
European Academy of Dermatology and Venereology Member
Lecluse, Lidian L.A.
Netherlands, Amsterdam
Bergman Clinics
Skov, Lone
Denmark, Hellerup
Gentofte Hospital
Denmark, Copenhagen
Københavns Universitet
Frez, Ma Lorna F.
Philippines, Manila
Philippine General Hospital
Babić, Lucija Tomić
Azerbaijan, Naftalan
Special Hospital for Medical Rehabilitation
Puíg, Lluís I.
Spain, Barcelona
Hospital de la Santa Creu I Sant Pau
Gomez, Luis Castro
Colombia, Bogota
Hospital Militar Central, Bogota
Ramam, Mandalaparthy
India, New Delhi
All India Institute of Medical Sciences, new Delhi
El-Sayed, Mahira Hamdy
Egypt, Cairo
Ain Shams University
Llamas Velasco, Maria Del Mar
Spain, Madrid
Hospital Universitario de la Princesa
Gonçalo, Margarida Margaria Martins
Portugal, Coimbra
Universidade de Coimbra
Rademaker, Marius
New Zealand, Auckland
The University of Auckland
Lebwohl, Mark Gabriel
United States, New York
Icahn School of Medicine at Mount Sinai
van Doorn, Martijn Bastiaan Adriaan
Netherlands, Rotterdam
Erasmus Mc
Gooderham, Melinda J.
Canada, Kingston
Queen’s University
Zheng, Min
China, Hangzhou
The Second Affiliated Hospital Zhejiang University School of Medicine
Doss, Néjib
Tunisia, Tunis
Golden Towers Médical Centre
Yawalkar, Nikhil Y.
Switzerland, Bern
University of Bern
Chosidow, Olivier
Unknown Affiliation
Calzavara-Pinton, Piergiacomo
Italy, Brescia
Università Degli Studi Di Brescia
Ghislain, Pierre Dominique
Unknown Affiliation
Romiti, Ricardo
Brazil, Sao Paulo
Universidade de São Paulo
Mahil, Satveer K.
United Kingdom, London
King's College London
Choon, Siew Eng
Malaysia, Bandar Sunway
Monash University Malaysia
Ayanlowo, Olusola O.
Nigeria, Lagos
University of Lagos
Gulliver, Wayne P.F.
Canada, St John's
Memorial University of Newfoundland
Statistics
Citations: 9
Authors: 118
Affiliations: 136
Identifiers
Doi:
10.1001/jamadermatol.2022.0434
ISSN:
21686068
Research Areas
Health System And Policy
Maternal And Child Health
Study Design
Cross Sectional Study
Study Approach
Quantitative