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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
A randomized trial of the impact of multiple micronutrient supplementation on mortality among HIV-infected individuals living in Bangkok
AIDS, Volume 17, No. 17, Year 2003
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Description
Objectives: To examine the impact of high-dose multiple micronutrient supplementation on survival and disease progression among HIV-infected individuals in Thailand. Design: Randomized placebo-controlled trial. Methods: Four-hundred and eighty-one HIV-infected men and women living in and around Bangkok with CD4 cell counts in the range 50 × 106-550 × 106/l were randomized to receive micronutrients or placebo for a period of 48 weeks. Trial participants were examined clinically 12-weekly and tested for CD4 cell count 24-weekly. A subset were tested for HIV plasma viral load at 48 weeks. Results: Seventy-nine (16%) trial participants were lost to follow-up and 23 (5%) died. The death rate was lower in the micronutrients arm with the mortality hazard ratios [95% confidence interval (CI)] of 0.53 (0.22-1.25; P = 0.1) overall and 0.37 (0.13-1.06; P = 0.052) and 0.26 (0.07-0.97; P = 0.03) among those with CD4 cell counts < 200 × 10 6/l and < 100 × 106/l respectively. There was no impact on CD4 cell count or plasma viral load. Conclusions: Multiple micronutrient supplementation may enhance the survival of HIV-infected individuals with CD4 cell counts < 200 × 106/l. This could have important public health implications in the developing world where access to antiretrovirals remains poor. The clinical findings need to be reproduced in other settings and the mechanism, which appears to be independent of change in CD4 cell count, merits further investigation. © 2003 Lippincott Williams & Wilkins.
Authors & Co-Authors
Pépin, Jacques
Canada, Sherbrooke
Université de Sherbrooke
Filteau, Suzanne M.
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Hanshaoworakul, Wanna
Thailand, Nontaburi
Thailand Ministry of Public Health
Jaffar, Shabbar S.
United Kingdom, London
London School of Hygiene & Tropical Medicine
United Kingdom, London
Medical Research Council
Statistics
Citations: 130
Authors: 4
Affiliations: 6
Identifiers
Doi:
10.1097/00002030-200311210-00008
ISSN:
02699370
Research Areas
Environmental
Health System And Policy
Infectious Diseases
Study Design
Cohort Study
Participants Gender
Male
Female