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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Age at menarche and menopause and breast cancer risk in the International BRCA1/2 Carrier Cohort Study
Cancer Epidemiology Biomarkers and Prevention, Volume 16, No. 4, Year 2007
Notification
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Description
Background: Early menarche and late menopause are important risk factors for breast cancer, but their effects on breast cancer risk in BRCA1 and BRCA2 carriers are unknown. Methods: We assessed breast cancer risk in a large series of 1,187 BRCA1 and 414 BRCA2 carriers from the International BRCA1/2 Carrier Cohort Study. Rate ratios were estimated using a weighted Cox-regression approach. Results: Breast cancer risk was not significantly related to age at menopause {hazard ratio [HR] for menopause below age 35 years, 0.60 [95% confidence interval (95% CI), 0.25-1.44]; 35 to 40 years, 1.15 [0.65-2.04]; 45 to 54 years, 1.02 [0.65-1.60]; ≥55 years, 1.12 [0.12-5.02], as compared with premenopausal women}. However, there was some suggestion of a reduction in risk after menopause in BRCA2 carriers. There was some evidence of a protective effect of oophorectomy (HR, 0.56; 95% CI, 0.29-1.09) and a significant trend of decreasing risk with increasing time since oophorectomy, but no apparent effect of natural menopause. There was no association between age at menarche and breast cancer risk, nor any apparent association with the estimated total duration of breast mitotic activity. Conclusions: These results are consistent with other observations suggesting a protective effect of oophorectomy, similar in relative effect to that in the general population. The absence of an effect of age at natural menopause is, however, not consistent with findings in the general population and may reflect the different natural history of the disease in carriers. Copyright © 2007 American Association for Cancer Research.
Authors & Co-Authors
Chang-Claude, Jenny C.
Germany, Heidelberg
German Cancer Research Center
Andrieu, Nadine
France, Paris
Inserm
France, Paris
Institut Curie
Rookus, Matti A.
Netherlands, Amsterdam
The Netherlands Cancer Institute
Brohet, Richard
Netherlands, Amsterdam
The Netherlands Cancer Institute
Antoniou, Antonis C.
United Kingdom, Cambridge
University of Cambridge
Peock, Susan
United Kingdom, Cambridge
University of Cambridge
United Kingdom, Glasgow
West of Scotland Regional Genetics Service
Davidson, Rosemarie H.
United Kingdom, Glasgow
Ferguson Smith Centre for Clinical Genetics
United Kingdom, London
The Royal Marsden Hospital
Izatt, Louise
United Kingdom, London
Guy's Hospital
United Kingdom, Sheffield
North Trent Clinical Genetics Service
Cole, Trevor R.P.
United Kingdom, Birmingham
Birmingham Women's Hospital
Noguès, Catherine
France, Saint-cloud
Centre René Huguenin
France, Nice
Centre Antoine Lacassagne
France, Reims
Institut Jean-godinot
Luporsi, Elisabethe
France, Vandoeouvre-les-nancy
Centre Alexis Vautrin
France, Clermont-ferrand
Centre Jean Perrin
Huiart, L.
France, Marseille
Institut Paoli-calmettes
France, Strasbourg
Hopital Civil
Hoogerbrugge, Nicoline
Netherlands, Nijmegen
Radboud University Medical Center
van Leeuwen, Flora Elizabeth
Netherlands, Amsterdam
The Netherlands Cancer Institute
Osorio, Ana
Spain, Madrid
Centro Nacional de Investigaciones Oncológicas
Eyfjörd, Jórunn Erla
Iceland, Reykjavik
Icelandic Cancer Society
Radice, Paolo
Italy, Milan
Fondazione Irccs Istituto Nazionale Dei Tumori, Milan
Italy, Milan
Fondazione Ifom Istituto Firc Di Oncologia Molecolare
Goldgar, David F.
France, Lyon
Centre International de Recherche Sur le Cancer
d'Adamo, Adamo P.
United Kingdom, Cambridge
University of Cambridge
Wagner, Teresa
Unknown Affiliation
Korn, Verena
Unknown Affiliation
Gerdes, Anne Marie Axø
Unknown Affiliation
Olàh, Edith
Unknown Affiliation
Eyford, Jorunn
Unknown Affiliation
Manoukian, Siranoush
Unknown Affiliation
Pierotti, Marco A.
Unknown Affiliation
Benit́ez, Javier J.
Unknown Affiliation
Caldés, Trinidad
Unknown Affiliation
de la Hoya, Miguel
Unknown Affiliation
Lubiński, Jan
Unknown Affiliation
Arver, Brita Wasteson
Unknown Affiliation
Olsson, Håkan L.
Unknown Affiliation
Loman, Niklas
Unknown Affiliation
Simard, Jacques
Unknown Affiliation
Sibille, Catherine
Unknown Affiliation
van Asperen, Christi J.
Netherlands, Leiden
Leids Universitair Medisch Centrum
Meijers-Heijboer, Hanne E.J.
Netherlands, Rotterdam
Erasmus Mc
Verhoef, Senno
United Kingdom, Cardiff
All Wales Medical Genetics Service
Vasen, Hans F.A.
Netherlands, Leiden
Netherlands Foundation for the Detection of Hereditary Tumors
Ausems, Margreet G.E.M.
Netherlands, Utrecht
University Medical Center Utrecht
Menko, Fred
Netherlands, Amsterdam
Amsterdam Umc - Vrije Universiteit Amsterdam
Gómez-Garćia, Encarna B.
Netherlands, Maastricht
Maastricht Universitair Medisch Centrum+
Cook, Margaret R.
United Kingdom, Glasgow
West of Scotland Regional Genetics Service
Engel, Cassandra
United Kingdom, Glasgow
West of Scotland Regional Genetics Service
Haites, Nneva E.
United Kingdom, London
Guy's Hospital
Gregory, Helen
United Kingdom, London
Guy's Hospital
Morrison, Patrick J.
Unknown Affiliation
McKeown, Carole M.E.
United Kingdom, Leicester
Leicestershire Clinical Genetics Service
Donaldson, Alan
United Kingdom, Leeds
Yorkshire Regional Genetics Service
Paterson, Joan S.
United Kingdom, Liverpool
Merseyside and Cheshire Clinical Genetics Service
Gray, J.
United Kingdom, Manchester
Regional Genetic Laboratories
Daly, Peter
United Kingdom, Nottingham
Nottingham University Hospitals Nhs Trust
Barton, David E.
United Kingdom, Nottingham
Nottingham University Hospitals Nhs Trust
Porteus, Mary
United Kingdom, Newcastle
Northern Regional Genetics Service
Steel, Michael C.
United Kingdom, Newcastle
Northern Regional Genetics Service
Brewer, Carole M.
United Kingdom, Oxford
Oxford Regional Genetics Service
Rankin, Julia
United Kingdom, Oxford
Oxford Regional Genetics Service
Murday, Victoria A.
United Kingdom, London
The Royal Marsden Hospital
Pichert, Gabriella
United Kingdom, Sheffield
North Trent Clinical Genetics Service
Dorkins, Huw R.
Unknown Affiliation
Trembath, Richard C.
United Kingdom, Southampton
Princess Anne Hospital
Bishop, D. Timothy
France, Saint-cloud
Centre René Huguenin
Chu, Carol E.
France, Saint-cloud
Centre René Huguenin
Ellis, Ian O.
France, Paris
Institut Curie
Evans, D. Gareth R.
United Kingdom, Manchester
Manchester Regional Genetics Service
Lalloo, Fiona I.
United Kingdom, Manchester
Manchester Regional Genetics Service
Shenton, Andrew
United Kingdom, Manchester
Manchester Regional Genetics Service
Mackay, James
France, Saint-cloud
Centre René Huguenin
Robinson, Anne C.R.
France, Saint-cloud
Centre René Huguenin
Ritchie, Susan
France, Strasbourg
Centre Paul Strauss Centre Régional de Lutte Contre le Cancer de Strasbourg
Douglas, Fiona S.
France, Lyon
Le Centre Régional de Lutte Contre le Cancer Léon Bérard
Burn, John
France, Lyon
Le Centre Régional de Lutte Contre le Cancer Léon Bérard
Durell, Sarah
France, Caen
Centre François Badesse
Side, Lucy E.
France, Caen
Centre François Badesse
Eeles, Ros A.
France, Vandoeouvre-les-nancy
Centre Alexis Vautrin
Cook, Jacqueline A.
France, Marseille
Institut Paoli-calmettes
Quarrell, Oliver W.J.
France, Marseille
Institut Paoli-calmettes
Hodgson, Shirley Victoria
France, Toulouse
Institut Claudius Regaud
Eccles, Diana M.
France, Angers
Centre Paul Papin
Lucassen, A. M.
France, Angers
Centre Paul Papin
Mouret-Fourme, Emmanuelle
France, Nice
Centre Antoine Lacassagne
Lidereau, Rosette
France, Nice
Centre Antoine Lacassagne
Stevens, Denise
France, Nice
Centre Antoine Lacassagne
Stoppa-Lyonnet, Dominique
Morocco, Agdal Rabat
Hôpital D'enfants
Gauthier-Villars, Marion
Morocco, Agdal Rabat
Hôpital D'enfants
Chompret, Agnès
France, Bordeaux
Institut Bergonie
Fricker, Jean Pierre
France, Niort
Ch Georges Renon
Lasset, Christine
France, Lille
Centre Oscar Lambret
Bonadona, Valérie
France, Lille
Centre Oscar Lambret
Berthet, Pascaline
France, Rouen
Hopital Charles Nicolle
Sobol, Hagay H.
France, Strasbourg
Hopital Civil
France, Marseille
Institut Paoli-calmettes
Eisinger, François A.
France, Strasbourg
Hopital Civil
Gladieff, Laurence
France, Rennes
Centre Eugène Marquis Rennes
Guimbaud, Rosine
France, Rennes
Centre Eugène Marquis Rennes
Lortholary, Alain H.
France, Reims
Polyclinique Courlancy
Frénay, Marc Paul
France, Marseille
Hopital la Timone
Faivre, Laurence Olivier
France, Avignon
Institut Sainte Catherine
Longy, Michel
France, Montpellier
Centre Hospitalier Universitaire de Montpellier
Nguyen, Tan Dat
France, Limoges
Hopital Dupuytren
Gesta, Paul H.
France, Paris
Institut Curie
Statistics
Citations: 100
Authors: 100
Affiliations: 56
Identifiers
Doi:
10.1158/1055-9965.EPI-06-0829
ISSN:
10559965
Research Areas
Cancer
Environmental
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Participants Gender
Female