Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Additional Selection for Insecticide Resistance in Urban Malaria Vectors: DDT Resistance in Anopheles arabiensis from Bobo-Dioulasso, Burkina Faso
PLoS ONE, Volume 7, No. 9, Article e45995, Year 2012
Notification
URL copied to clipboard!
Description
In the city of Bobo-Dioulasso in Burkina Faso, Anopheles arabiensis has superseded Anopheles gambiae s.s. as the major malaria vector and the larvae are found in highly polluted habitats normally considered unsuitable for Anopheles mosquitoes. Here we show that An. gambiae s.l. adults emerging from a highly polluted site in the city centre (Dioulassoba) have a high prevalence of DDT resistance (percentage mortality after exposure to diagnostic dose = 65.8% in the dry season and 70.4% in the rainy season, respectively). An investigation into the mechanisms responsible found an unexpectedly high frequency of the 1014S kdr mutation (allele frequency = 0.4), which is found at very low frequencies in An. arabiensis in the surrounding rural areas, and an increase in transcript levels of several detoxification genes, notably from the glutathione transferase and cytochrome P450 gene families. A number of ABC transporter genes were also expressed at elevated levels in the DDT resistant An. arabiensis. Unplanned urbanisation provides numerous breeding grounds for mosquitoes. The finding that Anopheles mosquitoes adapted to these urban breeding sites have a high prevalence of insecticide resistance has important implications for our understanding of the selective forces responsible for the rapid spread of insecticide resistant populations of malaria vectors in Africa. © 2012 Jones et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3457957/bin/pone.0045995.s001.xlsx
https://efashare.b-cdn.net/share/pmc/articles/PMC3457957/bin/pone.0045995.s002.xlsx
https://efashare.b-cdn.net/share/pmc/articles/PMC3457957/bin/pone.0045995.s003.xlsx
https://efashare.b-cdn.net/share/pmc/articles/PMC3457957/bin/pone.0045995.s004.xlsx
https://efashare.b-cdn.net/share/pmc/articles/PMC3457957/bin/pone.0045995.s005.xlsx
Authors & Co-Authors
Jones, Christopher M.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Toé, Hyacinthe K.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Burkina Faso, Ouagadougou
Centre Muraz
Burkina Faso, Ouagadougou
Centre National de Recherche et de Formation Sur le Paludisme
Sanou, Antoine
Burkina Faso, Ouagadougou
Centre National de Recherche et de Formation Sur le Paludisme
Namountougou, Moussa
Burkina Faso, Ouagadougou
Centre Muraz
Hughes, Angela J.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Diabaté, Abdoulaye
Burkina Faso, Ouagadougou
Centre Muraz
Dabiré, Roch Kounbobr
Burkina Faso, Ouagadougou
Centre Muraz
Simard, Frédéric R.
Burkina Faso, Ouagadougou
Centre Muraz
France, Montpellier
Maladies Infectieuses et Vecteurs : Écologie, Génétique, Évolution et Contrôle
Ranson, Hilary A.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Statistics
Citations: 95
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1371/journal.pone.0045995
e-ISSN:
19326203
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Burkina Faso