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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Heart type fatty acid binding protein, a marker of myocardial ischemia in children with epilepsy
Journal of Pediatric Neurology, Volume 11, No. 3, Year 2013
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Description
To evaluate ictal serum levels of heart type fatty acid binding protein (H-FABP) in children with intractable epilepsy as a marker of cardiac ischemia in comparison to their levels in the interictal period and that of controls. The study included 23 seizure episodes recorded in 14 patients with intractable seizures. Serum levels of H-FABP in the ictal and interictal periods were done as well as simultaneous electrocardiogram, Holter and video electroencephalography recordings with evaluation of changes in the heart rate (HR), and HR variability parameters. Levels of H-FABP were higher in the patients' group whether in the ictal or interictal periods compared to the control group. However, levels were not significantly different in the ictal period compared to the interictal one. Ictal tachycardia was recorded in 95% and bradycardia in 5% of the studied seizures episodes. Premature atrial and ventricular contractions were recorded in the 1st postictal hour of 8.7% and 30.4% of the recorded seizures, respectively. Interictal values showed significant increase minutes before the onset of the seizures and remained high 2 hours postictally. All time domain HR variability parameters were lower in the patients' group. Our results showed significant increase in the serum levels of H-FABP in our patients' group, which might suggest a degree of myocardial ischemia even in asymptomatic patients. Though bradycardia, prolonged QTc and arrhythmic changes were reported in few cases, the importance of the results warrants studying those changes at least in patients with refractory seizures. © 2013 IOS Press and the authors.
Authors & Co-Authors
Tomoum, Hoda Yahya
Egypt, Heliopolis
Faculty of Medicine
Aly, R. H.
Egypt, Heliopolis
Faculty of Medicine
Youssef, Omneya Ibrahim
Egypt, Heliopolis
Faculty of Medicine
Abdelal, Hala
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Nour, Mohamed Osama
Egypt, Heliopolis
Faculty of Medicine
El Sharkasy, Amina H.
Egypt, Heliopolis
Faculty of Medicine
Statistics
Citations: 6
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.3233/JPN-130621
e-ISSN:
18759041
Research Areas
Maternal And Child Health
Noncommunicable Diseases
Study Design
Randomised Control Trial