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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
The use of transient expression systems for the rapid production of virus-like particles in plants
Current Pharmaceutical Design, Volume 19, No. 31, Year 2013
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Description
Advances in transient expression technologies have allowed the production of milligram quantities of proteins within a matter of days using only small amounts (tens of grams) of plant tissue. Among the proteins that have been produced using this approach are the structural proteins of viruses which are capable of forming virus-like particles (VLPs). As such particulate structures are potent stimulators of the immune system, they are excellent vaccine candidates both in their own right and as carriers of additional immunogenic sequences. VLPs of varying complexity derived from a variety of animal viruses have been successfully transiently expressed in plants and their immunological properties assessed. Generally, the plant-produced VLPs were found to have the expected antigenicity and immunogenicity. In several cases, including an M2e-based influenza vaccine candidate, the plant-expressed VLPs have been shown to be capable of stimulating protective immunity. These findings raise the prospect that low-cost plant-produced vaccines could be developed for both veterinary and human use. © 2013 Bentham Science Publishers.
Authors & Co-Authors
Thuenemann, Eva C.
United Kingdom, Norwich
John Innes Centre
Lenzi, Paolo
United Kingdom, Norwich
John Innes Centre
Love, Andrew J.
United Kingdom, Aberdeen
The James Hutton Institute
Taliansky, Michael
United Kingdom, Aberdeen
The James Hutton Institute
Bécares, Martina
Spain, Madrid
Universidad Autónoma de Madrid
Zuñiga, Sonia
Spain, Madrid
Universidad Autónoma de Madrid
Enjuanes, Luis
Spain, Madrid
Universidad Autónoma de Madrid
Zahmanova, Gergana G.
Bulgaria, Plovdiv
Paisii Hilendarski University of Plovdiv
Minkov, Ivan N.
Bulgaria, Plovdiv
Genomics Research Center
Matić, Slavica
Italy, Turin
Istituto Per la Protezione Sostenibile Delle Piante, Consiglio Nazionale Delle Ricerche
Noris, Emanuela
Italy, Turin
Istituto Per la Protezione Sostenibile Delle Piante, Consiglio Nazionale Delle Ricerche
Meyers, Ann E.
South Africa, Cape Town
University of Cape Town
Hattingh, Alta
South Africa, Cape Town
University of Cape Town
Rybicki, Edward P.
South Africa, Cape Town
University of Cape Town
Kiselev, Oleg I.
Russian Federation, Moscow
Ministry of Health of Russian Federation
Ravin, Nikolai V.
Russian Federation, Moscow
Institute of Bioengineering, Moscow
Eldarov, Michael A.
Russian Federation, Moscow
Institute of Bioengineering, Moscow
Skryabin, Konstantin G.
Russian Federation, Moscow
Institute of Bioengineering, Moscow
Lomonossoff, George P.
United Kingdom, Norwich
John Innes Centre
Statistics
Citations: 59
Authors: 19
Affiliations: 9
Identifiers
Doi:
10.2174/1381612811319310011
ISSN:
13816128
e-ISSN:
18734286