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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Liver X receptors interfere with the deleterious effect of diethylstilbestrol on testicular physiology
Biochemical and Biophysical Research Communications, Volume 446, No. 3, Year 2014
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Description
Liver X receptors LXRα (NR1H3) and LXRβ (NR1H2) are transcription factors belonging to the nuclear receptor superfamily, activated by specific oxysterols, oxidized derivatives of cholesterol. These receptors are involved in the regulation of testis physiology. Lxr-deficient mice pointed to the physiological roles of these nuclear receptors in steroid synthesis, lipid homeostasis and germ cell apoptosis and proliferation. Diethylstilbestrol (DES) is a synthetic estrogen considered as an endocrine disruptor that affects the functions of the testis. Various lines of evidences have made a clear link between estrogens, their nuclear receptors ERα (NR3A1) and ERβ (NR3A2), and Lxrα/β. As LXR activity could also be regulated by the nuclear receptor small heterodimer partner (SHP, NR0A2) and DES could act through SHP, we wondered whether LXR could be targeted by estrogen-like endocrine disruptors such as DES. For that purpose, wild-type and Lxr-deficient mice were daily treated with 0.75 μg DES from days 1 to 5 after birth. The effects of DES were investigated at 10 or 45 days of age. We demonstrated that DES induced a decrease of the body mass at 10 days only in the Lxr-deficient mice suggesting a protective effect of Lxr. We defined three categories of DES-target genes in testis: those whose accumulation is independent of Lxr; those whose accumulation is enhanced by the lack of both Lxrα/β; those whose accumulation is repressed by the absence of Lxrα/β. Lipid accumulation is also modified by neonatal DES injection. Lxr-deficient mice present different lipid profiles, demonstrating that DES could have its effects in part due to Lxrα/β. Altogether, our study shows that both nuclear receptors Lxrα and Lxrβ are not only basally important for testicular physiology but could also have a preventive effect against estrogen-like endocrine disruptors. © 2013 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Oumeddour, Abdelkader
France, Clermont-ferrand
Université Clermont Auvergne
France, Paris
Cnrs Centre National de la Recherche Scientifique
France, Clermont-ferrand
Génétique Reproduction et Développement Gred
France, Clermont-ferrand
Crnh Centre de Recherche en Nutrition Humaine D'auvergne
Algeria, Annaba
Université Badji Mokhtar - Annaba
Viennois, Émilie
France, Clermont-ferrand
Université Clermont Auvergne
France, Paris
Cnrs Centre National de la Recherche Scientifique
France, Clermont-ferrand
Génétique Reproduction et Développement Gred
France, Clermont-ferrand
Crnh Centre de Recherche en Nutrition Humaine D'auvergne
Caira, Françoise
France, Clermont-ferrand
Université Clermont Auvergne
France, Paris
Cnrs Centre National de la Recherche Scientifique
France, Clermont-ferrand
Génétique Reproduction et Développement Gred
France, Clermont-ferrand
Crnh Centre de Recherche en Nutrition Humaine D'auvergne
Decourbey, Clélia
France, Clermont-ferrand
Université Clermont Auvergne
France, Paris
Cnrs Centre National de la Recherche Scientifique
France, Clermont-ferrand
Génétique Reproduction et Développement Gred
France, Clermont-ferrand
Crnh Centre de Recherche en Nutrition Humaine D'auvergne
Maqdasy, Salwan
France, Clermont-ferrand
Université Clermont Auvergne
France, Paris
Cnrs Centre National de la Recherche Scientifique
France, Clermont-ferrand
Génétique Reproduction et Développement Gred
France, Clermont-ferrand
Crnh Centre de Recherche en Nutrition Humaine D'auvergne
France, Clermont-ferrand
Centre Hospitalier Universitaire de Clermont-ferrand
Tahraoui, Abdelkrim
Algeria, Annaba
Université Badji Mokhtar - Annaba
Baron, Silvère
France, Clermont-ferrand
Université Clermont Auvergne
France, Paris
Cnrs Centre National de la Recherche Scientifique
France, Clermont-ferrand
Génétique Reproduction et Développement Gred
France, Clermont-ferrand
Crnh Centre de Recherche en Nutrition Humaine D'auvergne
Volle, David H.
France, Clermont-ferrand
Université Clermont Auvergne
France, Paris
Cnrs Centre National de la Recherche Scientifique
France, Clermont-ferrand
Génétique Reproduction et Développement Gred
France, Clermont-ferrand
Crnh Centre de Recherche en Nutrition Humaine D'auvergne
Lobaccaro, Jean Marc Adolphe
France, Clermont-ferrand
Université Clermont Auvergne
France, Paris
Cnrs Centre National de la Recherche Scientifique
France, Clermont-ferrand
Génétique Reproduction et Développement Gred
France, Clermont-ferrand
Crnh Centre de Recherche en Nutrition Humaine D'auvergne
Statistics
Citations: 9
Authors: 9
Affiliations: 6
Identifiers
Doi:
10.1016/j.bbrc.2013.12.005
ISSN:
0006291X
e-ISSN:
10902104
Research Areas
Cancer
Maternal And Child Health