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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Seroprevalence of antibodies against human papillomavirus (HPV) types 16 and 18 in four continents: The International Agency for Research on Cancer HPV prevalence surveys
Cancer Epidemiology Biomarkers and Prevention, Volume 19, No. 9, Year 2010
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Description
Background: Few human papillomavirus (HPV) seroprevalence studies have been carried out in women from low-resource countries. Methods: Seroprevalence of antibodies against HPV16 and HPV18 was assessed in 7,074 women ≥15 years of age (median 44 years) from eight world areas. Serum antibodies against HPV16 and HPV18 were tested for using enzyme-linked immunosorbent assay. HPV DNA was assessed using a general primer GP5 +/6+-mediated PCR. Results: HPV16 and HPV18 seroprevalence both ranged from <1% (Hanoi, Vietnam) to ≥25% (Nigeria). Of women who were HPV16 or HPV18 DNA-positive, seropositivity for the same type was 39.8% and 23.2%, respectively. Seropositivity for either type was directly associated with markers of sexual behavior. HPV16 and/or 18 (HPV16/18)- seropositive women had an increased risk of having cytologic abnormalities only if they were also HPV DNA-positive. A high international correlation was found between HPV16/18 seroprevalence and overall HPV DNA prevalence (r = 0.81; P = 0.022). However, HPV16/18 seroprevalence was substantially higher than the corresponding DNA prevalence in all study areas (although to different extents) and, contrary to DNA, tended to increase from young to middle age, and then decline or remain fairly constant. In all study areas, the vast majority of the information on the burden of exposure to HPV16/18 derived from serology. Conclusions: The correlation between HPV DNA and HPV serology was not very good at an individual woman level, but high at a population level. Impact: HPV serology is a poor marker of current infection or related lesions, but it can contribute, together with DNA, in evaluating the variations in the burden of HPV infection worldwide. ©2010 AACR.
Authors & Co-Authors
Vaccarella, Salvatore
France, Lyon
Centre International de Recherche Sur le Cancer
Franceschi, Silvia F.
France, Lyon
Centre International de Recherche Sur le Cancer
Clifford, Gary M.
France, Lyon
Centre International de Recherche Sur le Cancer
Touzé, Antoine
France, Tours
Université de Tours
Hsu, Charles C.
United States, San Francisco
University of California, San Francisco
de Sanjosé, Sílvia
Spain, Hospitalet de Llobregat
Institute Catala Oncologia
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Anh, Pham Thi Hoang
Viet Nam, Hanoi
National Cancer Institute
Hieu, Nguyen Trong
Viet Nam, Ho Chi Minh City
Hung Vuong Hospital
Matos, Elena Lina
Argentina, Buenos Aires
Universidad de Buenos Aires
Shin, Hairim
France, Lyon
Centre International de Recherche Sur le Cancer
South Korea, Goyang
National Cancer Centre
Sukvirach, Sukhon
Thailand
National Cancer Institute Thailand
Thomas, Jaiyeola O.
Nigeria, Ibadan
University of Ibadan
Boursaghin, Latifa
France, Tours
Université de Tours
France, Rennes
Faculté de Pharmacie
Gaitan, Julien
France, Tours
Université de Tours
Snijders, Peter Jf
Netherlands, Amsterdam
Amsterdam Umc - Vrije Universiteit Amsterdam
Meijer, Chris J.L.M.
Netherlands, Amsterdam
Amsterdam Umc - Vrije Universiteit Amsterdam
Muñoz, Nubia
Colombia, Bogota
Instituto Nacional de Cancerología
Herrero, Rolando
Costa Rica, Tres Rios
Instituto Costarricense de Investigacion y Ensenanza en Nutricion y Salud Costa Rica
Coursaget, Pierre L.
France, Tours
Université de Tours
Statistics
Citations: 54
Authors: 19
Affiliations: 15
Identifiers
Doi:
10.1158/1055-9965.EPI-10-0336
ISSN:
10559965
Research Areas
Cancer
Genetics And Genomics
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Study Locations
Nigeria
Participants Gender
Female