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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Potent cross-reactive antibodies following Omicron breakthrough in vaccinees
Cell, Volume 185, No. 12, Year 2022
Notification
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Description
Highly transmissible Omicron variants of SARS-CoV-2 currently dominate globally. Here, we compare neutralization of Omicron BA.1, BA.1.1, and BA.2. BA.2 RBD has slightly higher ACE2 affinity than BA.1 and slightly reduced neutralization by vaccine serum, possibly associated with its increased transmissibility. Neutralization differences between sub-lineages for mAbs (including therapeutics) mostly arise from variation in residues bordering the ACE2 binding site; however, more distant mutations S371F (BA.2) and R346K (BA.1.1) markedly reduce neutralization by therapeutic antibody Vir-S309. In-depth structure-and-function analyses of 27 potent RBD-binding mAbs isolated from vaccinated volunteers following breakthrough Omicron-BA.1 infection reveals that they are focused in two main clusters within the RBD, with potent right-shoulder antibodies showing increased prevalence. Selection and somatic maturation have optimized antibody potency in less-mutated epitopes and recovered potency in highly mutated epitopes. All 27 mAbs potently neutralize early pandemic strains, and many show broad reactivity with variants of concern. © 2022 The Author(s)
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC9120130/bin/mmc2.mp4
https://efashare.b-cdn.net/share/pmc/articles/PMC9120130/bin/mmc3.mp4
https://efashare.b-cdn.net/share/pmc/articles/PMC9120130/bin/mmc1.pdf
Authors & Co-Authors
Nutalai, Rungtiwa
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Zhou, Daming
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Tuekprakhon, Aekkachai
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Ginn, Helen Mary
United Kingdom, Didcot
Diamond Light Source
Supasa, Piyada
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Liu, Chang
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Huo, Jiangdong
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Mentzer, Alexander J.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
Duyvesteyn, Helen M.E.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Skelly, Dónal Thomas
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
United Kingdom, Oxford
Nuffield Department of Medicine
United Kingdom, Oxford
University of Oxford
Ritter, Thomas G.
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
Amini, Ali
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
United Kingdom, Oxford
Nuffield Department of Medicine
United Kingdom, Oxford
University of Oxford
Bibi, Sagida
United Kingdom, Oxford
University of Oxford
Adele, Sandra
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
Johnson, Síle Ann
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
Constantinides, Bede
United Kingdom, Oxford
University of Oxford
Webster, Hermione J.
United Kingdom, Oxford
University of Oxford
Temperton, Nigel James
United Kingdom, Chatham
Medway School of Pharmacy
Klenerman, Paul
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
United Kingdom, Oxford
Nuffield Department of Medicine
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
Barnes, Eleanor J.
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
United Kingdom, Oxford
Nuffield Department of Medicine
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
Dunachie, Susanna J.
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
United Kingdom, Oxford
Nuffield Department of Medicine
United Kingdom, Oxford
University of Oxford
Thailand, Bangkok
Mahidol Oxford Tropical Medicine Research Unit
Crook, Derrick W.M.
United Kingdom, Oxford
University of Oxford
Pollard, Andrew J.
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
Lambe, Teresa
United Kingdom, Oxford
University of Oxford
Goulder, Philip Jeremy Renshaw
United Kingdom, Oxford
Nuffield Department of Medicine
United Kingdom, Oxford
University of Oxford
Paterson, Neil G.
United Kingdom, Didcot
Diamond Light Source
Williams, Mark A.
United Kingdom, Didcot
Diamond Light Source
Hall, David Richard
United Kingdom, Didcot
Diamond Light Source
Mongkolsapaya, Juthathip
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Fry, Elizabeth E.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Dejnirattisai, Wanwisa
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Ren, Jingshan
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Stuart, David Ian
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
United Kingdom, Didcot
Diamond Light Source
Screaton, Gavin Robert
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Statistics
Citations: 65
Authors: 34
Affiliations: 8
Identifiers
Doi:
10.1016/j.cell.2022.05.014
ISSN:
00928674
Study Design
Cross Sectional Study
Study Approach
Qualitative