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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Keratinocyte sensitization to tumour necrosis factor-induced nuclear factor kappa B activation by the E2 regulatory protein of human papillomaviruses
Journal of General Virology, Volume 92, No. 10, Year 2011
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Description
Human papillomavirus (HPV) life cycle requires extensive manipulation of cell signalling to provide conditions adequate for viral replication within the stratified epithelia. In this regard, we show that the E2 regulatory protein of α, β and m-HPV genotypes enhances tumour necrosis factor (TNF)-induced activation of nuclear factor kappa B (NF-kB). This activation is mediated by the Nterminal domain of E2, but does not rely on its transcriptional properties. It is independent of the NF-kB regulator Tax1BP1, which nevertheless interacts with all the E2 proteins. E2 specifically activates NF-kB pathways induced by TNF, while interleukin-1-induced pathways are not affected. E2 stimulates the activating K63-linked ubiquitination of TRAF5, and interacts with both TRAF5 and TRAF6. Our data suggest that E2 potentiates TNF-induced NF-kB signalling mediated by TRAF5 activation through direct binding. Since NF-kB controls epithelial differentiation, this activity may be involved in the commitment of infected keratinocytes to proliferation arrest and differentiation, both required for the implementation of the productive viral cycle. © 2011 SGM.
Authors & Co-Authors
Boulabiar, Manel
Tunisia, Tunis
Institut Pasteur de Tunis
France, Paris
Institut Pasteur, Paris
Boubaker, Samir
Tunisia, Tunis
Institut Pasteur de Tunis
Favre, Michel
France, Paris
Institut Pasteur, Paris
Demeret, Caroline
France, Paris
Institut Pasteur, Paris
Statistics
Citations: 16
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1099/vir.0.032466-0
ISSN:
00221317
e-ISSN:
14652099
Research Areas
Cancer