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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Dietary exposure to aflatoxin and fumonisin among Tanzanian children as determined using biomarkers of exposure
Molecular Nutrition and Food Research, Volume 57, No. 10, Year 2013
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Description
Scope: The study aims to evaluate the status of dietary exposure to aflatoxin and fumonisin in young Tanzanian children, using previously validated biomarkers of exposure. Methods and results: A total of 148 children aged 12-22 months, were recruited from three geographically distant villages in Tanzania; Nyabula, Kigwa, and Kikelelwa. Plasma aflatoxin-albumin adducts (AF-alb) and urinary fumonisin B1 (UFB1) were measured by ELISA and LC-MS, respectively. AF-alb was detectable in 84% of children, was highest in fully weaned children (p < 0.01) with higher levels being associated with higher maize intake (p < 0.05). AF-alb geometric mean (95% CI) was 43.2 (28.7-65.0), 19.9 (13.5-29.2), and 3.6 (2.8-4.7) pg/mg albumin in children from Kigwa, Nyabula, and Kikelelwa, respectively. UFB1 was detectable in 96% of children and the level was highest in children who had been fully weaned (p < 0.01). The geometric UFB1 mean (95% CI) was 327.2 (217.1-493.0), 211.7 (161.1-278.1), and 82.8 (58.3-117.7) pg/mL in Kigwa, Nyabula, and Kikelelwa, respectively. About 82% of all the children were exposed to both mycotoxins. Conclusion: Young children in Tanzania are chronically exposed to both aflatoxin and fumonisin through contaminated diet, although the level of exposure varies markedly between the three villages studied. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Authors & Co-Authors
Shirima, Candida P.
United Kingdom, Leeds
University of Leeds, School of Medicine
Tanzania, Dar es Salaam
Tanzania Food and Drugs Authority
Tanzania, Morogoro
Sokoine University of Agriculture
Kimanya, Martin Epafras
Tanzania, Dar es Salaam
Tanzania Food and Drugs Authority
Tanzania, Arusha
Nelson Mandela African Institution of Science and Technology
Kinabo, Joyce Ludovick D.
Tanzania, Morogoro
Sokoine University of Agriculture
Routledge, Michael N.
United Kingdom, Leeds
University of Leeds, School of Medicine
Srey, Chou
United Kingdom, Leeds
University of Leeds, School of Medicine
Wild, Christopher Paul
France, Lyon
Centre International de Recherche Sur le Cancer
Gong, Yun Yun
United Kingdom, Leeds
University of Leeds, School of Medicine
United Kingdom, Belfast
Queen's University Belfast
Statistics
Citations: 104
Authors: 7
Affiliations: 6
Identifiers
Doi:
10.1002/mnfr.201300116
ISSN:
16134125
e-ISSN:
16134133
Research Areas
Maternal And Child Health
Study Locations
Tanzania