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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Whole-genome analysis of diverse Chlamydia trachomatis strains identifies phylogenetic relationships masked by current clinical typing
Nature Genetics, Volume 44, No. 4, Year 2012
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Description
Chlamydia trachomatis is responsible for both trachoma and sexually transmitted infections, causing substantial morbidity and economic cost globally. Despite this, our knowledge of its population and evolutionary genetics is limited. Here we present a detailed phylogeny based on whole-genome sequencing of representative strains of C. trachomatis from both trachoma and lymphogranuloma venereum (LGV) biovars from temporally and geographically diverse sources. Our analysis shows that predicting phylogenetic structure using ompA, which is traditionally used to classify Chlamydia, is misleading because extensive recombination in this region masks any true relationships present. We show that in many instances, ompA is a chimera that can be exchanged in part or as a whole both within and between biovars. We also provide evidence for exchange of, and recombination within, the cryptic plasmid, which is another key diagnostic target. We used our phylogenetic framework to show how genetic exchange has manifested itself in ocular, urogenital and LGV C. trachomatis strains, including the epidemic LGV serotype L2b. © 2012 Nature America, Inc. All rights reserved.
Authors & Co-Authors
Harris, Simon R.
Unknown Affiliation
Clarke, Ian N.
Unknown Affiliation
Seth-Smith, Helena M.B.
Unknown Affiliation
Solomon, Anthony W.
Unknown Affiliation
Cutcliffe, Lesley T.
Unknown Affiliation
Marsh, Peter
Unknown Affiliation
Skilton, Rachel J.
Unknown Affiliation
Holland, Martin J.
Unknown Affiliation
Mabey, David C.W.
Unknown Affiliation
Peeling, Rosanna Wai Wan
Unknown Affiliation
LEWIS, D. A.
Unknown Affiliation
Spratt, Brian G.
Unknown Affiliation
Unemo, Magnus
Unknown Affiliation
Persson, Kenneth
Unknown Affiliation
Bjartling, Carina
Unknown Affiliation
Brunham, Robert C.
Unknown Affiliation
de Vries, Henry J.C.
Unknown Affiliation
Morré, Servaas Å.
Unknown Affiliation
Speksnijder, Arjen
Unknown Affiliation
Bébéar, Cécile Marie
Unknown Affiliation
Clerc, Maïthé Thérèse
Unknown Affiliation
De-Barbeyrac, Bertillle Marie
Unknown Affiliation
Parkhill, Julian
Unknown Affiliation
Thomson, Nicholas Robert
Unknown Affiliation
Statistics
Citations: 298
Authors: 24
Affiliations: 19
Identifiers
Doi:
10.1038/ng.2214
ISSN:
10614036
e-ISSN:
15461718
Research Areas
Genetics And Genomics
Sexual And Reproductive Health
Study Design
Cross Sectional Study