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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Liposomes as an ocular delivery system of fluconazole: In-vitro studies
Acta Ophthalmologica, Volume 88, No. 8, Year 2010
Notification
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Description
Purpose: To study the clinical effect of topical controlled-release ophthalmic fluconazole liposomal formulation and to compare its effect with fluconazole solution in a reproducible model of Candida keratitis in rabbits. Methods: Forty adult rabbits were included in this study. Right eyes were inoculated with freshly prepared Caindida albicans strain no. 4925 and showed signs of infected keratitis. The rabbits were divided randomly into two groups: in the first group (18 rabbits) the right eyes received fluconazole solution, while in the second group (22 rabbits) the right eyes received fluconazole-loaded liposomes. The rabbits' eyes were examined daily over a 21-day period and results were recorded. Results: Rabbits infected with C. albicans responded better and showed more improvement in terms of size of ulcer and hypopyon using fluconazole-loaded liposomal formulae than using fluconazole solution. In the first group (solution), nine rabbits' cornea showed complete healing (50%) at the end of third week while in group 2 (liposome), 19 rabbits' cornea showed complete healing (86.4%) at equal duration. These results were statistically significant. Conclusion: Therapy with topical liposomal fluconazole (2 mg/ml) was successful in eliminating experimental C. albicans infection of the rabbit cornea and was superior to fluconazole solution. Journal compilation © 2009 Acta Ophthalmol.
Authors & Co-Authors
Habib, Fawzia Sayed
Egypt, Asyut
Faculty of Pharmacy
Fouad, Ehab Ahmad
Egypt, Asyut
Faculty of Pharmacy
Abdel-Rhaman, Mohamed S.
Egypt, Asyut
Faculty of Medicine
Fathalla, Dina
Egypt, Asyut
Faculty of Pharmacy
Statistics
Citations: 80
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1111/j.1755-3768.2009.01584.x
ISSN:
1755375X
e-ISSN:
17553768
Research Areas
Health System And Policy