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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
TB meningitis in HIV-positive patients in Europe and Argentina: Clinical dutcome and factors associated with mortality
BioMed Research International, Volume 2013, Article 373601, Year 2013
Notification
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Description
Objectives. The study aimed at describing characteristics and outcome of tuberculous meningitis (TBM) in HIV-positive patients and comparing these parameters with those of extrapulmonary TB (TBEP) and pulmonary TB (TBP). Methods. Kaplan-Meier estimation and Poisson regression models were used to assess the mortality following TB diagnosis and to evaluate potential prognostic factors for the 3 groups of TB patients separately. Results. A total of 100 patients with TBM, 601 with TBEP, and 371 TBP were included. Patients with TBM had lower CD4 cell counts and only 17.0% received antiretroviral therapy (ART) at TB diagnosis. The cumulative probability of death at 12 months following TB was 51.2% for TBM (95% CI 41.4-61.6%), 12.3% for TBP (8.9-15.7%), and 19.4% for TBEP (16.1-22.6) (P < 0.0001; log-rank test). For TBM, factors associated with a poorer prognosis were not being on ART (adjusted incidence rate ratio (aIRR) 4.00 (1.72-9.09), a prior AIDS diagnosis (aIRR = 4.82 (2.61-8.92)), and receiving care in Eastern Europe (aIRR = 5.41 (2.58-11.34))). Conclusions. TBM among HIV-positive patients was associated with a high mortality rate, especially for patients from Eastern Europe and patients with advanced HIV-infection, which urgently calls for public health interventions to improve both TB and HIV aspects of patient management. © 2013 Anne Marie W. Efsen et al.
Authors & Co-Authors
Panteleev, Alexander M.
Unknown Affiliation
Rakhmanova, Aza Gasanovna
Unknown Affiliation
Losso, Marcelo Horacio
Argentina, Buenos Aires
Hospital J.m. Ramos Mejia, Buenos Aires
Miller, Robert F.
United Kingdom, London
University College London
Girardi, Enrico
Italy, Rome
Irccs Istituto Nazionale Malattie Infettive Lazzaro Spallanzani
Caylà, Joan A.
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Post, Frank A.
United Kingdom, London
Faculty of Life Sciences & Medicine
Miró, José María
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Bruyand, Mathias
France, Talence
Centre Hospitalier Universitaire de Bordeaux
France, Paris
Inserm
Furrer, Hansjakob
Switzerland, Bern
University of Bern
Obel, Niels
Denmark, Copenhagen
Rigshospitalet
Lundgren, Jens D.
Denmark, Copenhagen
Københavns Universitet
Denmark, Copenhagen
Rigshospitalet
Mocroft, Amanda J.
United Kingdom, London
University College London
Kirk, Ole
Denmark, Copenhagen
Københavns Universitet
Denmark, Copenhagen
Rigshospitalet
Corral, Jorge A.
Unknown Affiliation
Laplumé, Héctor E.
Unknown Affiliation
David, Daniel O.
Unknown Affiliation
Lupo, Sergio Horacio
Unknown Affiliation
Karpov, Igor Alexandrovich
Unknown Affiliation
Gerstoft, Jan
Unknown Affiliation
Kronborg, Gitte
Unknown Affiliation
Pedersen, Court K.
Unknown Affiliation
Larsen, Carsten Schade
Unknown Affiliation
Laursen, Alex Lund
Unknown Affiliation
Dabis, Franćois Ç.Ois
Unknown Affiliation
Chêne, Geneviève
Unknown Affiliation
Thíébaut, Rodolphe
Unknown Affiliation
Wittkop, Linda
Unknown Affiliation
Morlat, Philippe
Unknown Affiliation
Bonnet, Fabrice
Unknown Affiliation
Vandenhende, Marianne
Unknown Affiliation
Longy-Boursier, Maïté
Unknown Affiliation
Malvy, Denis Jean Marie
Unknown Affiliation
Pistone, Thierry
Unknown Affiliation
Receveur, Marie Catherine
Unknown Affiliation
Pellegrin, Jean Luc
Unknown Affiliation
Viallard, Jean François
Unknown Affiliation
Lazaro, Estibaliz
Unknown Affiliation
Fleury, Hervè J.A.
Unknown Affiliation
Lafon, Marie Édith
Unknown Affiliation
Reigadas, Sandrine
Unknown Affiliation
Trimoulet, Pascale
Unknown Affiliation
Molimard, Mathieu
Unknown Affiliation
Titier, Karine
Unknown Affiliation
Haramburu, Fraņcoise
Unknown Affiliation
Dupont, Alain
Unknown Affiliation
André, Katell
Unknown Affiliation
Farbos, Sophie
Unknown Affiliation
Ceccaldi, Joël
Unknown Affiliation
Tchamgouè, Serge
Unknown Affiliation
Monlun, Eric
Unknown Affiliation
Gaborieau, Valérie
Unknown Affiliation
Carvalho, Anna Cristina Calcada
Unknown Affiliation
Maggiolo, Franco
Unknown Affiliation
Ravasio, Veronica
Unknown Affiliation
Mussini, Cristina
Unknown Affiliation
Antinori, Andrea
Unknown Affiliation
Bellagamba, Rita
Unknown Affiliation
Cicalini, Stefania
Unknown Affiliation
Di Caro, Antonino
Unknown Affiliation
Goletti, Delia
Unknown Affiliation
Grisetti, Susanna
Unknown Affiliation
Gualano, Gina
Unknown Affiliation
Lauria, Francesco Nicola
Unknown Affiliation
Palmieri, Fabrizio
Unknown Affiliation
Petrosillo, Nicola
Unknown Affiliation
Sampaolesi, Alessandro
Unknown Affiliation
Angarano, Gioacchino
Unknown Affiliation
D'Arminio Monforte, Antonella D.
Unknown Affiliation
Castelli, Francesco
Unknown Affiliation
Cauda, Roberto
Unknown Affiliation
Di Perri, Giovanni
Unknown Affiliation
Galli, Massimo
Unknown Affiliation
Iardino, Rosaria
Unknown Affiliation
Ippolito, Giuseppe
Unknown Affiliation
Lazzarin, Adriano
Unknown Affiliation
Perno, Carlo Federico
Unknown Affiliation
Viale, Pierluigi
Unknown Affiliation
Castagna, Antonella
Unknown Affiliation
Ceccherini-Silberstein, Francesca
Unknown Affiliation
Cozzi-Lepri, Alessandro
Unknown Affiliation
Lo Caputo, Sergio
Unknown Affiliation
Puoti, Massimo
Unknown Affiliation
Andreoni, Massimo G.
Unknown Affiliation
Balotta, Claudia
Unknown Affiliation
Bonfanti, Paolo
Unknown Affiliation
Bonora, Stefano
Unknown Affiliation
Borderi, Marco
Unknown Affiliation
Capobianchi, Maria Rosaria
Unknown Affiliation
Cingolani, A.
Unknown Affiliation
Cinque, P.
Unknown Affiliation
de Luca, Andrea
Unknown Affiliation
Di Biagio, Antonio
Unknown Affiliation
Gianotti, Nicola
Unknown Affiliation
Gori, Andrea
Unknown Affiliation
Guaraldi, Giovanni
Unknown Affiliation
Lapadula, Giuseppe
Unknown Affiliation
Lichtner, Miriam
Unknown Affiliation
Monno, Laura
Unknown Affiliation
Quiròs-Roldan, Eugenia
Unknown Affiliation
Rusconi, Stefano
Unknown Affiliation
Cicconi, Paola
Unknown Affiliation
Fanti, Iuri
Unknown Affiliation
Galli, Luisa
Unknown Affiliation
Lorenzini, Patrizia
Unknown Affiliation
Giacometti, Andrea R.
Unknown Affiliation
Verucchi, Gabriella
Unknown Affiliation
Quirino, Tiziana
Unknown Affiliation
Segala, D.
Unknown Affiliation
Mastroianni, Claudio Maria
Unknown Affiliation
Rizzardini, Giuliano
Unknown Affiliation
Ridolfo, Anna Lisa
Unknown Affiliation
Carenzi, Laura
Unknown Affiliation
Chirianni, Antonio
Unknown Affiliation
Parruti, Giustino
Unknown Affiliation
Ursini, T.
Unknown Affiliation
Vullo, Vincenzo
Unknown Affiliation
Nicastri, Emanuele
Unknown Affiliation
Acinapura, Rosa
Unknown Affiliation
Cattelan, Anna María
Unknown Affiliation
Caramello, Pietro
Unknown Affiliation
Orofino, Giancarlo
Unknown Affiliation
Pellizzer, Giampietro P.
Unknown Affiliation
Manfrin, Vinicio
Unknown Affiliation
Riekstiņa, Vieja
Unknown Affiliation
Duiculescu, Dan Constantin
Unknown Affiliation
García-Goéz, José Fernando
Unknown Affiliation
Martínez, Jaime Antonio Serrano
Unknown Affiliation
González, Julià
Unknown Affiliation
de Làzzari, Elisa
Unknown Affiliation
Gatell, José Mariá A.
Unknown Affiliation
Falcó, Vicenç
Unknown Affiliation
Imaz, Arkaitz
Unknown Affiliation
Samb́eat, María Antònia
Unknown Affiliation
Moreno-Martínez, Asunción
Unknown Affiliation
Weber, Rainer
Unknown Affiliation
Battegay, Manuel
Unknown Affiliation
Hirschel, Bernard J.
Unknown Affiliation
Cavassini, Matthias
Unknown Affiliation
Bernasconi, Enos
Unknown Affiliation
Schmid, Patrick
Unknown Affiliation
Rickenbach, Martin
Unknown Affiliation
Campbell, Lucy J.
Unknown Affiliation
Arenas-Pinto, Alejandro
Unknown Affiliation
Kjaer, Jesper
Unknown Affiliation
Statistics
Citations: 11
Authors: 145
Affiliations: 11
Identifiers
Doi:
10.1155/2013/373601
ISSN:
23146133
Research Areas
Health System And Policy
Infectious Diseases
Study Design
Cohort Study