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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Identification of human papillomavirus type 58 lineages and the distribution worldwide
Journal of Infectious Diseases, Volume 203, No. 11, Year 2011
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Description
Background. Human papillomavirus type 58 (HPV-58) accounts for a much higher proportion of cervical cancers in East Asia than other types. A classification system of HPV-58, which is essential for molecular epidemiological study, is lacking. Methods and results. This study analyzed the sequences of 401 isolates collected from 15 countries and cities. The 268 unique concatenated E6-E7-E2-E5-L1-LCR sequences that comprised 57% of the whole HPV-58 genome showed 4 distinct clusters. L1 and LCR produced tree topologies that best resembled the concatenated sequences and thus are the most appropriate surrogate regions for lineage classification. Moreover, short fragments from L1 (nucleotides 6014-6539) and LCR (nucleotides 7257-7429 and 7540-52) were found to contain sequence signatures informative for lineage identification. Lineage A was the most prevalent lineage across all regions. Lineage C was more frequent in Africa than elsewhere, whereas lineage D was more prevalent in Africa than in Asia. Among lineage A variants, sublineage A2 dominated in Africa, the Americas, and Europe, but not in Asia. Sublineage A1, which represents the prototype that originated from a patient with cancer, was rare worldwide except in Asia. Conclusions. HPV-58 can be classified into 4 lineages that show some degree of ethnogeographic predilection in distribution. The evolutionary, epidemiological, and pathological characteristics of these lineages warrant further study. © The Author 2011. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC6281402/bin/jir157_Supplementary_Data.zip
Authors & Co-Authors
Chan, Kay Sheung Paul
Hong Kong, Hong Kong
Chinese University of Hong Kong, Faculty of Medicine
Luk, Alfred C.S.
Hong Kong, Hong Kong
Chinese University of Hong Kong, Faculty of Medicine
Park, Jong Sup
South Korea, Seoul
The Catholic University of Korea Seoul St. Mary's Hospital
Smith-McCune, Karen K.
United States, San Francisco
University of California, San Francisco
United States, San Francisco
Ucsf Helen Diller Family Comprehensive Cancer Center
Palefsky, Joel Michael
United States, San Francisco
Ucsf School of Medicine
Konno, Ryo
Japan, Kawachi District
Jichi Medical University
Giovannelli, Lucia
Italy, Palermo
Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone
Coutlée, François
Canada, Montreal
Centre Hospitalier de L'universite de Montreal
Hibbitts, Sam J.
United Kingdom, Cardiff
Cardiff University
Chu, Tang Yuan
Taiwan, Hualien
Tzu Chi University
Settheetham-Ishida, Wannapa
Thailand, Khon Kaen
Khon Kaen University
Picconi, María Alejandra
Argentina, Buenos Aires
Instituto Nacional de Enfermedades Infecciosas
Ferrera, Annabelle
Honduras, Tegucigalpa
Universidad Nacional Autónoma de Honduras
De Marco, Federico
Italy, Rome
Irccs Regina Elena National Cancer Institute
Woo, Y. L.
United Kingdom, Cambridge
University of Cambridge
Raiol, Tainá
Brazil, Brasilia
Universidade de Brasília
Piña-Sánchez, Patricia
Mexico, Mexico
Umae Hospital de Oncología Centro Medico Nacional Siglo Xxi
Cheung, Jo L.K.
Hong Kong, Hong Kong
Chinese University of Hong Kong, Faculty of Medicine
Bae, Jeong Hoon
South Korea, Seoul
The Catholic University of Korea Seoul St. Mary's Hospital
Chirenje, Mike Zvavahera
Zimbabwe, Harare
University of Zimbabwe
Magure, Tsitsi Mildred
Zimbabwe, Harare
University of Zimbabwe
Mościcki, Anna Barbara
United States, San Francisco
Ucsf Helen Diller Family Comprehensive Cancer Center
United States, San Francisco
University of California, San Francisco
Fiander, Alison Nina
United Kingdom, Cardiff
Cardiff University
Stefano, Rosa Di
Italy, Palermo
Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone
Cheung, Tak Hong
Hong Kong
Prince of Wales Hospital Hong Kong
Yu, May M.Y.
Hong Kong
Prince of Wales Hospital Hong Kong
Tsui, Stephen Kwok Wing
Hong Kong, Hong Kong
Chinese University of Hong Kong
Pim, David
Italy, Trieste
International Centre for Genetic Engineering and Biotechnology
Banks, Lawrence
Italy, Trieste
International Centre for Genetic Engineering and Biotechnology
Statistics
Citations: 46
Authors: 29
Affiliations: 21
Identifiers
Doi:
10.1093/infdis/jir157
ISSN:
00221899
Research Areas
Cancer
Health System And Policy