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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Human spumavirus antibodies in sera from African patients
Archives of Virology, Volume 123, No. 3-4, Year 1992
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Description
Serum samples collected from patients with a wide variety of diseases from African and other countries were tested for antibodies to the human spumaretrovirus (HSRV). A spumaviral env-specific ELISA was employed as screening test. Out of 3020 human sera screened, 106 were found to be positive (3.2%). While the majority of patients' sera from Europe (1581) were negative, 26 were positive (1.6%). Sera from healthy adult blood donors (609), from patients with multiple sclerosis (48), Graves' disease (45), and chronic fatigue syndrome (41) were negative or showed a very low prevalence for spumaviral env antibodies. A higher percentage of seropositives (6.3%) were found among 1338 African patients from Tanzania, Kenya, and Gabon. Out of 1180 patients from Tanzania, 708 suffered from tumors, 75 from AIDS, and 128 had gynecological problems; 51 of the Tanzanian patients were HSRV seropositive (4.3%). A particularly high percentage of 16.6% seropositives were identified among nasopharyngeal carcinoma patients (NPC) from Kenya and Tanzania consistent with results reported 10 years ago. However, 20 nasopharyngeal carcinoma patients from Malaysia were HSRV-seronegative. In selected cases, sera from seropositive individuals were reacted with proteins from HSRV-infected cells in vitro. HSRV env-and gag-specific antibodies were specifically detected by these sera in Western blots. The results indicate spumavirus infections in human patients with various diseases at a relatively low prevalence worldwide; in African patients, however, the prevalence of spumavirus infections is markedly higher. © 1992 Springer-Verlag.
Authors & Co-Authors
Mahnke, C.
Germany, Heidelberg
Projektgruppe Humane Retroviren
Kashaiya, P.
Tanzania, Dar es Salaam
Ocean Road Hospital
Rössler, J.
Germany, Heidelberg
Projektgruppe Humane Retroviren
Bannert, H.
Germany, Heidelberg
Projektgruppe Humane Retroviren
Levin, Arthur G.
United Kingdom, London
Mrc Clinical Research Centre
Blattner, William A.
United States, Rockville
National Cancer Institute Nci
Dietrich, Manfred
Germany, Hamburg
Bernhard Nocht Institut Fur Tropenmedizin Hamburg
Luande, Jeffrey
Tanzania, Dar es Salaam
Ocean Road Hospital
Löchelt, Martin
Germany, Heidelberg
Projektgruppe Humane Retroviren
Friedman-Kien, Alvin E.
United States, New York
Nyu Langone Health
Komaroff, A. L.
United States, Boston
Brigham and Women's Hospital
Loh, P. C.
United States, Honolulu
University of Hawaiʻi at Mānoa
Westarp, M. E.
Germany, Ulm
Rku - Universitäts- Und Rehabilitationskliniken Ulm Ggmbh
Flügel, R. M.
Germany, Heidelberg
Projektgruppe Humane Retroviren
Statistics
Citations: 14
Authors: 14
Affiliations: 9
Identifiers
Doi:
10.1007/BF01317261
ISSN:
03048608
e-ISSN:
14328798
Research Areas
Cancer
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Gabon
Kenya
Tanzania