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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Immune recognition of Candida albicans β-glucan by dectin-1
Journal of Infectious Diseases, Volume 196, No. 10, Year 2007
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Description
β(1,3)-glucans represent 40% of the cell wall of the yeast Candida albicans. The dectin-1 lectin-like receptor has shown to recognize fungal β(1,3)-glucans and induce innate immune responses. The importance of β-glucan-dectin-1 pathways for the recognition of C. albicans byhumanprimary blood cells has not been firmly established. In this study we demonstrate that cytokine production by both human peripheral blood mononuclear cells and murine macrophages is dependent on the recognition of β-glucans by dectin-1. Heat killing of C. albicans resulted in exposure of β-glucans on the surface of the cell wall and subsequent recognition by dectin-1, whereas live yeasts stimulated monocytes mainly via recognition of cell-surface mannans. Dectin-1 induced cytokine production through the following 2 pathways: Syk-dependent production of the T-helper (Th) 2-type anti-inflammatory cytokine interleukin-10 and Toll-like receptor-Myd88-dependent stimulation of monocyte-derived proinflammatory cytokines, such as tumor necrosis factor-α. In contrast, stimulation of Th1-type cytokines, such as interferon-γ, by C. albicans was independent of the recognition of β-glucans by dectin-1. In conclusion, C. albicans induces production of monocyte-derived and T cell- derived cytokines through distinct pathways dependent on or independent of dectin-1. © 2007 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Gow, Neil A.R.
United Kingdom, Aberdeen
University of Aberdeen School of Medicine, Medical Sciences and Nutrition
Netea, Mihai Gheorghe
Netherlands, Nijmegen
Radboud University Medical Center
Munro, Carol A.
United Kingdom, Aberdeen
University of Aberdeen School of Medicine, Medical Sciences and Nutrition
Ferwerda, Gerben
Netherlands, Nijmegen
Radboud University Medical Center
Bates, Steven
United Kingdom, Aberdeen
University of Aberdeen School of Medicine, Medical Sciences and Nutrition
Mora-Montes, Héctor Manuel
United Kingdom, Aberdeen
University of Aberdeen School of Medicine, Medical Sciences and Nutrition
Walker, Louise A.
United Kingdom, Aberdeen
University of Aberdeen School of Medicine, Medical Sciences and Nutrition
Jansen, Trees
Netherlands, Nijmegen
Radboud University Medical Center
Jacobs, Liesbeth
Netherlands, Nijmegen
Radboud University Medical Center
Tsoni, Vicky
South Africa, Cape Town
University of Cape Town
Brown, Gordon D.A.
South Africa, Cape Town
University of Cape Town
Odds, Frank C.
United Kingdom, Aberdeen
University of Aberdeen School of Medicine, Medical Sciences and Nutrition
van der Meer, Jos W.M.D.
Netherlands, Nijmegen
Radboud University Medical Center
Brown, Alistair J.P.
United Kingdom, Aberdeen
University of Aberdeen School of Medicine, Medical Sciences and Nutrition
Kullberg, Bart Jan
Netherlands, Nijmegen
Radboud University Medical Center
Statistics
Citations: 15
Authors: 15
Affiliations: 3
Identifiers
Doi:
10.1086/523110
ISSN:
00221899
Research Areas
Cancer