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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
neuroscience
Human motor plasticity induced by mirror visual feedback
Journal of Neuroscience, Volume 32, No. 4, Year 2012
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Description
The clinical use of mirror visual feedback (MVF) was initially introduced to alleviate phantom pain, and has since been applied to the improvement of hemiparesis following stroke. However, it is not known whether MVF can restore motor function by producing plastic changes in the human primary motor cortex (M1). Here, we used transcranial magnetic stimulation to test whether M1 plasticity is a physiological substrate of MVF-induced motor behavioral improvement. MVF intervention in normal volunteers using a mirror box improved motor behavior and enhanced excitatory functions of the M1. Moreover, behavioral and physiological measures of MVF-induced changes were positively correlated with each other. Improved motor performance occurred after observation of a simple action, but not after repetitive motor training of the nontarget hand without MVF, suggesting the crucial importance of visual feedback. The beneficial effects of MVF were disrupted by continuous theta burst stimulation (cTBS) over the M1, but not the control site in the occipital cortex. However, MVF following cTBS could further improve the motor functions. Our findings indicate that M1 plasticity, especially in its excitatory connections, is an essential component of MVF-based therapies. © 2012 the authors.
Authors & Co-Authors
Nojima, Ippei
Japan, Kobe
Kobe University
Japan, Kyoto
Graduate School of Medicine
Mima, Tatsuya
Japan, Kyoto
Graduate School of Medicine
Koganemaru, Satoko
Japan, Kyoto
Graduate School of Medicine
Thabit, Mohamed Nasreldin
Japan, Kyoto
Graduate School of Medicine
Egypt, Sohag
Faculty of Medicine
Fukuyama, Hironori
Japan, Kyoto
Graduate School of Medicine
Kawamata, Toshio
Japan, Kobe
Kobe University
Statistics
Citations: 166
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1523/JNEUROSCI.5364-11.2012
ISSN:
02706474
e-ISSN:
15292401
Research Areas
Noncommunicable Diseases
Study Design
Randomised Control Trial