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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
The African coelacanth genome provides insights into tetrapod evolution
Nature, Volume 496, No. 7445, Year 2013
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Description
The discovery of a living coelacanth specimen in 1938 was remarkable, as this lineage of lobe-finned fish was thought to have become extinct 70 million years ago. The modern coelacanth looks remarkably similar to many of its ancient relatives, and its evolutionary proximity to our own fish ancestors provides a glimpse of the fish that first walked on land. Here we report the genome sequence of the African coelacanth, Latimeria chalumnae. Through a phylogenomic analysis, we conclude that the lungfish, and not the coelacanth, is the closest living relative of tetrapods. Coelacanth protein-coding genes are significantly more slowly evolving than those of tetrapods, unlike other genomic features. Analyses of changes in genes and regulatory elements during the vertebrate adaptation to land highlight genes involved in immunity, nitrogen excretion and the development of fins, tail, ear, eye, brain and olfaction. Functional assays of enhancers involved in the fin-to-limb transition and in the emergence of extra-embryonic tissues show the importance of the coelacanth genome as a blueprint for understanding tetrapod evolution. © 2013 Macmillan Publishers Limited. All rights reserved.
Authors & Co-Authors
Amemiya, Chris T.
United States, Seattle
Benaroya Research Institute at Virginia Mason
United States, Seattle
University of Washington
Alfoldi, Jessica
United States, Cambridge
Broad Institute
Lee, Alison P.
Singapore, Singapore City
A-star, Institute of Molecular and Cell Biology
Fan, Shaohua
Germany, Konstanz
Universität Konstanz
Philippe, Hervé
Canada, Montreal
Robert Cedergren Centre
MacCallum, Iain
United States, Cambridge
Broad Institute
Braasch, Ingo
United States, Eugene
University of Oregon
Manousaki, Tereza
Germany, Konstanz
Universität Konstanz
Schneider, Igor
Brazil, Belem
Universidade Federal do Pará
Rohner, Nicolas
United States, Boston
Harvard Medical School
Organ, Chris L.
United States, Salt Lake City
The University of Utah
Chalopin, Domitille
France, Lyon
École Normale Supérieure de Lyon
Smith, Jeramiah J.
United States, Lexington
University of Kentucky
Robinson, Mark D.
United States, Seattle
Benaroya Research Institute at Virginia Mason
Dorrington, Rosemary Ann
South Africa, Grahamstown
Rhodes University
Gerdol, Marco
Italy, Trieste
Università Degli Studi Di Trieste
Aken, Bronwen L.
United Kingdom, Hinxton
Wellcome Sanger Institute
Biscotti, Maria Assunta
Italy, Ancona
Università Politecnica Delle Marche
Barucca, Marco
Italy, Ancona
Università Politecnica Delle Marche
Baurain, Denis
Belgium, Liege
Université de Liège
Berlin, Aaron M.
United States, Cambridge
Broad Institute
Blatch, Gregory Lloyd
South Africa, Grahamstown
Rhodes University
Australia, Melbourne
Victoria University
Buonocore, Francesco
Italy, Viterbo
Università Degli Studi Della Tuscia Viterbo
Burmester, Thorsten
Germany, Hamburg
Universität Hamburg
Campbell, Michael S.
United States, Salt Lake City
University of Utah Health
Canapa, Adriana
Italy, Ancona
Università Politecnica Delle Marche
Cannon, John P.
United States, Tampa
Morsani College of Medicine
Christoffels, Alan G.
South Africa, Bellville
University of the Western Cape
De Moro, Gianluca
Italy, Trieste
Università Degli Studi Di Trieste
Edkins, Adrienne Lesley
South Africa, Grahamstown
Rhodes University
Fan, Lin
United States, Cambridge
Broad Institute
Fausto, Anna Maria
Italy, Viterbo
Università Degli Studi Della Tuscia Viterbo
Feiner, Nathalie
Germany, Konstanz
Universität Konstanz
Forconi, Mariko
Italy, Ancona
Università Politecnica Delle Marche
Gamieldien, Junaid
South Africa, Bellville
University of the Western Cape
Gnerre, Sante
United States, Cambridge
Broad Institute
Gnirke, Andreas
United States, Cambridge
Broad Institute
Goldstone, Jared V.
United States, Woods Hole
Woods Hole Oceanographic Institution
Haerty, Wilfried
United Kingdom, Oxford
University of Oxford
Hahn, Mark E.
United States, Woods Hole
Woods Hole Oceanographic Institution
Hesse, Uljana
South Africa, Bellville
University of the Western Cape
Hoffmann, Steve
Germany, Leipzig
Universität Leipzig
Johnson, Jeremy K.
United States, Cambridge
Broad Institute
Karchner, Sibel I.
United States, Woods Hole
Woods Hole Oceanographic Institution
Kuraku, Shigehiro
Germany, Konstanz
Universität Konstanz
Japan, Wako
Riken
Lara, Marcia
United States, Cambridge
Broad Institute
Levin, Joshua Z.
United States, Cambridge
Broad Institute
Litman, Gary W.
United States, Tampa
Morsani College of Medicine
Mauceli, Evan W.
United States, Cambridge
Broad Institute
United States, Boston
Boston Children's Hospital
Miyake, Tsutomu
Japan, Tokyo
Keio University
Mueller, M. Gail
United States, St Petersburg
All Children's Hospital St. Petersburg
Nelson, David R.
United States, Memphis
University of Tennessee Health Science Center
Nitsche, Anne
Germany, Leipzig
Universität Leipzig
Olmo, Ettore
Italy, Ancona
Università Politecnica Delle Marche
Ota, Tatsuya
Japan, Hayama
The Graduate University for Advanced Studies
Pallavicini, Alberto
Italy, Trieste
Università Degli Studi Di Trieste
Panji, Sumir
South Africa, Bellville
University of the Western Cape
South Africa, Cape Town
University of Cape Town
Picone, Barbara
South Africa, Bellville
University of the Western Cape
Ponting, Chris Paul
United Kingdom, Oxford
University of Oxford
Prohaska, Sonja J.
Germany, Leipzig
Universität Leipzig
Przybylski, Dariusz
United States, Cambridge
Broad Institute
Saha, Nil Ratan
United States, Seattle
Benaroya Research Institute at Virginia Mason
Ravi, Vydianathan
Singapore, Singapore City
A-star, Institute of Molecular and Cell Biology
Ribeiro, Filipe J.
United States, Cambridge
Broad Institute
United States, New York
New York Genome Center
Sauka-Spengler, Tatjana
United Kingdom, Oxford
Mrc Weatherall Institute of Molecular Medicine
Scapigliati, Giuseppe
Italy, Viterbo
Università Degli Studi Della Tuscia Viterbo
Searle, Stephen M.J.
United Kingdom, Hinxton
Wellcome Sanger Institute
Sharpe, Ted
United States, Cambridge
Broad Institute
Simakov, Oleg
Germany, Konstanz
Universität Konstanz
Germany, Heidelberg
European Molecular Biology Laboratory Heidelberg
Stadler, Peter F.
Germany, Leipzig
Universität Leipzig
Stegeman, John J.
United States, Woods Hole
Woods Hole Oceanographic Institution
Sumiyama, Kenta
Japan, Mishima
National Institute of Genetics Mishima
Tabbaa, Diana
United States, Cambridge
Broad Institute
Tafer, Hakim
Germany, Leipzig
Universität Leipzig
Turner-Maier, Jason
United States, Cambridge
Broad Institute
van Heusden, Peter A.
South Africa, Bellville
University of the Western Cape
White, Simon
United Kingdom, Hinxton
Wellcome Sanger Institute
Williams, Louise
United States, Cambridge
Broad Institute
Yandell, Mark D.
United States, Salt Lake City
University of Utah Health
Brinkmann, Henner
Canada, Montreal
Robert Cedergren Centre
Volff, Jean Nicolas
France, Lyon
École Normale Supérieure de Lyon
Tabin, Clifford J.
United States, Boston
Harvard Medical School
Shubin, Neil H.
United States, Chicago
The University of Chicago
Schartl, Manfred
Germany, Wurzburg
Julius-maximilians-universität Würzburg
Jaffe, David B.
United States, Cambridge
Broad Institute
Postlethwait, John H.
United States, Eugene
University of Oregon
Venkatesh, Byrappa
Singapore, Singapore City
A-star, Institute of Molecular and Cell Biology
Di-Palma, Federica
United States, Cambridge
Broad Institute
Lander, Eric S.
United States, Cambridge
Broad Institute
Meyer, Axel
Germany, Konstanz
Universität Konstanz
Lindblad-Toh, Kerstin
United States, Cambridge
Broad Institute
Sweden, Uppsala
Uppsala Universitet
Statistics
Citations: 510
Authors: 91
Affiliations: 40
Identifiers
Doi:
10.1038/nature12027
ISSN:
00280836
e-ISSN:
14764687
Research Areas
Health System And Policy