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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Plasmodium falciparum clearance rates in response to artesunate in Malian children with malaria: Effect of acquired immunity
Journal of Infectious Diseases, Volume 207, No. 11, Year 2013
Notification
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Description
Background. Artemisinin resistance, a long parasite clearance half-life in response to artemisinin, has been described in patients with Plasmodium falciparum malaria in southeast Asia. Few baseline half-lives have been reported from Africa, where artemisinins were recently introduced.Methods. We treated P. falciparum malaria in 215 Malian children aged 0.5-15 years with artesunate (0, 24, 48 hours) and amodiaquine (72, 96, 120 hours). We estimated half-life by measuring parasite density every 6 hours until undetectable and evaluated the effects of age, sex, ethnicity, and red blood cell (RBC) polymorphisms on half-life. We quantified the proportion of parasitized RBCs recognized by autologous immunoglobulin G (IgG).Results. The geometric mean half-life was 1.9 hours (95% confidence interval, 1.8-2.0) and did not correlate with parasite ex vivo susceptibility to artemisinins. In a linear model accounting for host factors, half-life decreased by 4.1 minutes for every 1-year increase in age. The proportion of parasitized RBCs recognized by IgG correlated inversely with half-life (r =-0.475; P =. 0006).Conclusions. Parasite clearance in response to artesunate is faster in Mali than in southeast Asia. IgG responses to parasitized RBCs shorten half-life and may influence this parameter in areas where age is not an adequate surrogate of immunity and correlates of parasite-clearing immunity have not been identified. © 2013 The Author.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3636783/bin/supp_207_11_1655__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC3636783/bin/supp_jit082_jit082supp.pdf
Authors & Co-Authors
Lopera-Mesa, Tatiana M.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Doumbia, Saibou
Mali, Bamako
University of Bamako Faculty of Medicine, Pharmacy and Odonto-stomatology
Chiang, Serena
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Zeituni, Amir E.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Konaté, Drissa S.
Mali, Bamako
University of Bamako Faculty of Medicine, Pharmacy and Odonto-stomatology
Doumbouya, Mory
Mali, Bamako
University of Bamako Faculty of Medicine, Pharmacy and Odonto-stomatology
Keita, Abdoul Salam
Mali, Bamako
University of Bamako Faculty of Medicine, Pharmacy and Odonto-stomatology
Stepniewska, K. A.
United Kingdom, Oxford
Nuffield Department of Medicine
Traoré, Karim
Mali, Bamako
University of Bamako Faculty of Medicine, Pharmacy and Odonto-stomatology
Diakité, Séidina Aboubacar Samba
Mali, Bamako
University of Bamako Faculty of Medicine, Pharmacy and Odonto-stomatology
Ndiaye, Daouda F.
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Sa, Juliana Martha
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Anderson, Jennifer M.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Fay, Michael P.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Long, Carole A.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Diakité, Mahamadou L.
Mali, Bamako
University of Bamako Faculty of Medicine, Pharmacy and Odonto-stomatology
Fairhurst, Rick M.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Statistics
Citations: 74
Authors: 17
Affiliations: 4
Identifiers
Doi:
10.1093/infdis/jit082
ISSN:
00221899
Research Areas
Infectious Diseases
Maternal And Child Health
Study Locations
Mali