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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Antibody levels against hepatitis B virus after hepatitis B vaccination in Egyptian diabetic children and adolescents
Human Vaccines and Immunotherapeutics, Volume 9, No. 9, Year 2013
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Description
Background: The remarkable effectiveness of universal infantile hepatitis B (HB) vaccination is well documented in many countries. Nevertheless, the influence of insulin-dependent diabetes mellitus (IDDM) on the sero-protective level of antibody to hepatitis B surface antigen (anti-HBs) after HB vaccination has not been investigated in Egyptian children. The aim of this study was to investigate long-term anti-HBs sero-protective levels after infantile HB vaccination in Egyptian IDDM children. Results: The mean age of the healthy children was 10.86 ± 1.21 y (range, 5.5-15 y); 49 (45.8%) were boys and 58 (54.2%) were girls. The mean age of the IDDM children was 10.29 ± 3.04 y (range, 4-17 y); 32 (50.8%) were boys and 31 (49.2%) were girls. There were no significant differences between the healthy and IDDM children with respect to age and sex (p > 0.05). Among the 107 healthy children, 43 (40%) did not have a protective anti-HBs level (anti-HBs < 10 IU/L) and 64 (60%) had a protective level (anti-HBs ≥ 10 IU/L). In contrast, among the IDDM children, 44 (69.8%) and 19 (30.2%) did not and did have protective anti-HBs levels, respectively. This difference in anti-HBs concentration between healthy and diabetic children was highly significant (p < 0.001). None of the vaccinated healthy or IDDM children was reactive to HBsAg or total anti-HBc. Patients and Methods: A total of 170 children (81 boys, 89 girls) who had been routinely vaccinated against HB were included. Their mean age was 10 ± 2.1 y. The enrolled children were divided into healthy (n = 107) and IDDM (n = 63) cohorts. Body Mass Index and levels of hepatitis B surface antigen (HBsAg), total antibody to hepatitis B core antigen (anti-HBc), and anti-HBs were evaluated in all children. In addition, the duration of diabetes mellitus (DM) and levels of glycated hemoglobin (HbA1c) were measured in IDDM children. Conclusion: Our results are alarming. It appears that the majority of Egyptian diabetic children vaccinated against HB may not have sufficient anti-HBs levels to protect them from HB. Moreover, this study emphasizes the need for a population-based strategy for the management of patients without an anti-HBs protective level after HB vaccination and justifies the need to elucidate the heritability of those children. © 2013 Landes Bioscience.
Authors & Co-Authors
Elrashidy, Heba
Egypt, Zagazig
Zagazig University
Elbahrawy, Ashraf
Egypt, Cairo
Faculty of Medicine
El-Didamony, Gamal
Egypt, Zagazig
Zagazig University
Mostafa, Mohamed
Egypt, Cairo
Al-azhar University
George, Nilly M.
Egypt, Zagazig
Zagazig University
Elwassief, Ahmed
Egypt, Cairo
Faculty of Medicine
Mohamed, Abdel Gawad Saeid
Egypt, Cairo
Faculty of Medicine
Elmestikawy, Amr
Egypt, Cairo
Faculty of Medicine
Morsy, Mohamed Hanafy
Egypt, Cairo
Al-azhar University
Hashim, Alaa
Egypt, Cairo
Al-azhar University
Abdelbasseer, Mohamed Ali
Egypt, Cairo
Al-azhar University
Statistics
Citations: 20
Authors: 11
Affiliations: 3
Identifiers
Doi:
10.4161/hv.25426
ISSN:
21645515
e-ISSN:
2164554X
Research Areas
Infectious Diseases
Maternal And Child Health
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study
Participants Gender
Male
Female