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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Levels and patterns of neutrophil cell counts over the first 8 years of life in children of HIV-1-infected mothers
AIDS, Volume 18, No. 15, Year 2004
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Description
Background: Antiretroviral drugs (ARV) as prophylaxis to prevent mother-to-child transmission of HIV results in decreased haematological parameters during and shortly after exposure, with recent data suggesting a more prolonged inhibition of haematopoiesis until at least 18 months. Design: Data on 156 HIV-infected and 1533 uninfected children in the European Collaborative Study followed from birth until at least 8 years of age. Methods: Smoothers and splines were used to elucidate patterns over age; linear mixed effects allowed for repeated measurements. Covariates included the child's HIV-1 infection status, prematurity, gender, race, drug withdrawal symptoms at birth and ARV exposure; effects on neutrophil count were quantified in regression analyses using z-scores (SD from mean) of neutrophil counts obtained after modelling untransformed values using the LMS method. For HIV-infected children, progression to AIDS and ARV therapy were also included. Results: After approximately 4 months of age, neutrophil counts were consistently and substantially lower in HIV-infected children than in uninfected children; in both groups, black children had significantly lower counts than white children across the whole age range. In uninfected children, male gender and ARV exposure were associated with reduced neutrophil count until at least 8 years of age. In HIV-infected children, advanced disease and ARV treatment were significantly associated with neutrophil count. Conclusion: A considerably longer effect of exposure to ARV was shown in uninfected children than previously thought and significant associations were shown between race and gender and neutrophil count, as previously observed for lymphocyte counts. The clinical relevance of these reduced levels of neutrophils requires further investigation. © 2004 Lippincott Williams & Wilkins.
Authors & Co-Authors
Bunders, Madeleine J.
United Kingdom, London
University College London
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Cortina-Borja, Mario J.F.
United Kingdom, London
University College London
Thorne, Claire N.
United Kingdom, London
University College London
Kuijpers, T. W.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Newell, Marie Louise
United Kingdom, London
University College London
Giaquinto, Carlo
Italy, Padua
Università Degli Studi Di Padova
Giacomet, Vania
Italy, Padua
Università Degli Studi Di Padova
De Rossi, Anita
Italy, Padua
Università Degli Studi Di Padova
Grosch-Wörner, Ilse
Germany, Berlin
Charité – Universitätsmedizin Berlin
Mok, Jacqueline Y.Q.
United Kingdom, Edinburgh
Royal Hospital for Sick Children
Bates, Isabel
Spain, Madrid
Hospital Materno-infantil
Hawkins, Federico Gustavo
Spain, Madrid
Hospital Materno-infantil
García Rodriguez, Marie Cruz
Spain, Madrid
Hospital Materno-infantil
González-García, Juan Julián
Spain, Madrid
Hospital Materno-infantil
Arribas, Jose R.
Spain, Madrid
Hospital Materno-infantil
Asensi-Botet, Francesc
Spain, Valencia
Hospital Universitari I Politècnic la fe
Otero, Ma Carmen
Spain, Valencia
Hospital Universitari I Politècnic la fe
Scherpbier, Henriëtte J.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Boer, Kees R.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Bohlin, Ann Britt
Sweden, Stockholm
Karolinska Universitetssjukhuset
Belfrage, Erik
Sweden, Stockholm
Karolinska Universitetssjukhuset
Navèr, Lars
Sweden, Stockholm
Karolinska Universitetssjukhuset
Lévy, Jack A.
Belgium, Brussels
Centre Hospitalier Universitaire Saint Pierre, Brussels
Hainaut, Marc
Belgium, Brussels
Centre Hospitalier Universitaire Saint Pierre, Brussels
Peltier, Alexandra
Belgium, Brussels
Centre Hospitalier Universitaire Saint Pierre, Brussels
Goetghebuer, Tessa
Belgium, Brussels
Centre Hospitalier Universitaire Saint Pierre, Brussels
Barlow, Patricia
Belgium, Brussels
Centre Hospitalier Universitaire Saint Pierre, Brussels
Ferrazin, Antonio
Italy, Genoa
Università Degli Studi Di Genova
Bassetti, Dante
Italy, Genoa
Università Degli Studi Di Genova
de Maria, Andrea F.
Italy, Genoa
Università Degli Studi Di Genova
Gotta, Cristina
Italy, Genoa
Università Degli Studi Di Genova
Mur-Sierra, Antonío
Spain, Barcelona
Hospital Del Mar
Paya, A.
Spain, Barcelona
Hospital Del Mar
Carreras, Ramón C.
Spain, Barcelona
Hospital Del Mar
Statistics
Citations: 82
Authors: 34
Affiliations: 12
Identifiers
Doi:
10.1097/00002030-200410210-00005
ISSN:
02699370
Research Areas
Infectious Diseases
Maternal And Child Health
Participants Gender
Male