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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Canine visceral leishmaniasis caused by Leishmania infantum in Senegal: Risk of emergence in humans?
Microbes and Infection, Volume 12, No. 14-15, Year 2010
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Description
In the context of global warming and the risk of spreading arthropod-borne diseases, the emergence and reemergence of leishmaniasis should not be neglected. In Senegal, over the past few years, cases of canine leishmaniasis have been observed. We aim to improve the understanding of the transmission cycle of this zoonosis, to determine the responsible species and to evaluate the risk for human health. An epidemiological and serological study on canine and human populations in the community of Mont Rolland (Thiès area) was conducted. The data showed a high seroprevalence of canine leishmaniasis (>40%) and more than 30% seropositive people. The dogs' seroprevalence was confirmed by PCR data (concordance > 0.85, Kappa > 0.7). The statistical analysis showed strong statistical associations between the health status of dogs and seropositivity, the number of positive PCRs, clinical signs and the number of Leishmania isolates. For the first time, the discriminative PCRs performed on canine Leishmania strains clearly evidenced that the pathogenic agent is Leishmania infantum. The results obtained show that transmission of this species is well established in this area. That the high incidence of seropositivity in humans may be a consequence of infection with this species is discussed. © 2010.
Authors & Co-Authors
Faye, Bernard
Senegal, Dakar
Universite Cheikh Anta Diop Faculte de Medecine et de Pharmacie
Anne-Laure, Bañuls Laure
France, Paris
Cnrs Centre National de la Recherche Scientifique
Bucheton, Bruno
France, Paris
Cirad
Dione, Michel Maïnack
Gambia, Banjul
International Trypanotolerance Centre Gambia
Bassanganam, O.
Senegal, Dakar
Universite Cheikh Anta Diop Faculte de Medecine et de Pharmacie
Hide, Mallorie
France, Paris
Cnrs Centre National de la Recherche Scientifique
Dereure, Jacques
France, Paris
Cnrs Centre National de la Recherche Scientifique
France, Montpellier
Université de Montpellier
Choisy, Marc
France, Paris
Cnrs Centre National de la Recherche Scientifique
Ndiaye, Jean Louis Abdourahim
Senegal, Dakar
Universite Cheikh Anta Diop Faculte de Medecine et de Pharmacie
Konaté, Oumar
Senegal, Dakar
Universite Cheikh Anta Diop Faculte de Medecine et de Pharmacie
Claire, M.
France, Paris
Cnrs Centre National de la Recherche Scientifique
Senghor, Massila Wagué
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Faye, Malick Ndao
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Sy, I.
Senegal, Dakar
Universite Cheikh Anta Diop Faculte de Medecine et de Pharmacie
Niang, Abdoul Aziz
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Molez, Jean François
Senegal, Dakar
Institut de Recherche Pour le Développement Dakar
Victoir, Kathleen
France, Paris
Institut Pasteur, Paris
Marty, Pierre M.
France, Nice
Centre Hospitalier Universitaire de Nice, Hôpital L'archet
Delaunay, Pascal
France, Nice
Centre Hospitalier Universitaire de Nice, Hôpital L'archet
Knecht, Romy
France, Nice
Centre Hospitalier Universitaire de Nice, Hôpital L'archet
Mellul, Sandra
France, Nice
Centre Hospitalier Universitaire de Nice, Hôpital L'archet
Diedhiou, Souleymane
Senegal, Dakar
Universite Cheikh Anta Diop Faculte de Medecine et de Pharmacie
Gaye, Oumar H.
Senegal, Dakar
Universite Cheikh Anta Diop Faculte de Medecine et de Pharmacie
Statistics
Citations: 26
Authors: 23
Affiliations: 9
Identifiers
Doi:
10.1016/j.micinf.2010.09.003
ISSN:
12864579
e-ISSN:
1769714X
Study Design
Cohort Study
Study Approach
Quantitative
Study Locations
Senegal