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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The in vivo antidiabetic activity of Nigella sativa is mediated through activation of the AMPK pathway and increased muscle Glut4 content
Evidence-based Complementary and Alternative Medicine, Volume 2011, Article 538671, Year 2011
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Description
The antidiabetic effect of N. sativa seed ethanol extract (NSE) was assessed in Meriones shawi after development of diabetes. Meriones shawi were divided randomly into four groups: normal control, diabetic control, diabetic treated with NSE (2geqplant/kg) or with metformin (300mg/kg) positive control, both administered by daily intragastric gavage for 4 weeks. Glycaemia and body weight were evaluated weekly. At study's end, an Oral Glucose Tolerance Test (OGTT) was performed to estimate insulin sensitivity. Upon sacrifice, plasma lipid profile, insulin, leptin, and adiponectin levels were assessed. ACC phosphorylation and Glut4 protein content were determined in liver and skeletal muscle. NSE animals showed a progressive normalization of glycaemia, albeit slower than that of metformin controls. Moreover, NSE increased insulinemia and HDL-cholesterol, compared to diabetic controls. Leptin and adiponectin were unchanged. NSE treatment decreased OGTT and tended to decrease liver and muscle triglyceride content. NSE stimulated muscle and liver ACC phosphorylation and increased muscle Glut4. These results confirm NSE's previously reported hypoglycaemic and hypolipidemic activity. More significantly, our data demonstrate that in vivo treatment with NSE exerts an insulin-sensitizing action by enhancing ACC phosphorylation, a major component of the insulin-independent AMPK signaling pathway, and by enhancing muscle Glut4 expression. Copyright © 2011 Ali Benhaddou-Andaloussi et al.
Authors & Co-Authors
Haddad, Pierre Sélim
Canada, Montreal
University of Montreal
Canada, Quebec
Institut Des Nutraceutiques et Des Aliments Fonctionnels, Canada
Benhaddou-Andaloussi, Ali
Canada, Montreal
University of Montreal
Canada, Quebec
Institut Des Nutraceutiques et Des Aliments Fonctionnels, Canada
Martineau, Louis Charles
Canada, Montreal
University of Montreal
Canada, Quebec
Institut Des Nutraceutiques et Des Aliments Fonctionnels, Canada
Vuong, Tri
Canada, Montreal
University of Montreal
Canada, Quebec
Institut Des Nutraceutiques et Des Aliments Fonctionnels, Canada
Meddah, Bouchra
Morocco, Rabat
Faculté de Médecine et de Pharmacie de Rabat
Madiraju, Padma
Canada, Montreal
University of Montreal
Canada, Quebec
Institut Des Nutraceutiques et Des Aliments Fonctionnels, Canada
Settaf, Abdellatif
Morocco, Rabat
Faculté de Médecine et de Pharmacie de Rabat
Statistics
Citations: 115
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1155/2011/538671
ISSN:
1741427X
e-ISSN:
17414288
Research Areas
Health System And Policy
Noncommunicable Diseases