Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Characteristics of hepatitis B virus in Ghana: Full length genome sequences indicate the endemicity of genotype E in West Africa
Journal of Medical Virology, Volume 78, No. 2, Year 2006
Notification
URL copied to clipboard!
Description
Hepatitis B virus (HBV) genotypes from A to H have distinct geographical distributions and have been shown to affect the clinical features as well as the course of the HBV infection. HBV genotype E has been found only in Africa. However, the complete genomes of this genotype, which were isolated mainly from West Africa, were available only for a few samples. In this study, five full-length genomes and seven other small S genes of HBV strains from Ghanaian blood donors were sequenced and investigated. Following phylogenetic analysis, all of the Ghanaian HBV strains were clustered closely in genotype E. All of the 12 small S genes showed the same characteristic of subtype ayw4. The complete genomes of the five Ghanaian strains showed marked similarity with each other and with the reported genotype E strains (96.7%-99.1%). Genotype E strains showed low intra-genotypic diversity (1.8%) and carried the conserved signature pattern in pre-S1 as well as in the full genome sequence. Of note, the finding of the G145R escape mutant in an unvaccinated Ghanaian blood donor might raise concern as to the ongoing nation-wide hepatitis B vaccination program in Ghana. © 2005 Wiley-Liss, Inc.
Authors & Co-Authors
Huy, Tran Thien Tuan
Japan, Tokyo
National Institute of Infectious Diseases
Japan, Tokyo
Graduate School of Medicine
Ishikawa, Koichi
Japan, Tokyo
National Institute of Infectious Diseases
Ghana, Accra
Noguchi Memorial Institute for Medical Research
Ampofo, William Kwabena
Ghana, Accra
Noguchi Memorial Institute for Medical Research
Izumi, Taku
Japan, Tokyo
National Institute of Infectious Diseases
Nakajima, Akira
Japan, Tokyo
National Institute of Infectious Diseases
Ansah, Justina
Ghana, Ghana
National Blood Service
Tetteh, John O.
Ghana, Ghana
National Blood Service
Nii-Trebi, Nicholas I.
Ghana, Accra
Noguchi Memorial Institute for Medical Research
Aidoo, Simeon
Ghana, Accra
Noguchi Memorial Institute for Medical Research
Ofori‐Adjei, David
Ghana, Accra
Noguchi Memorial Institute for Medical Research
Sata, Tetsutaro
Japan, Tokyo
National Institute of Infectious Diseases
Ushijima, Hiroshi
Japan, Tokyo
Graduate School of Medicine
Abe, Kenji
Japan, Tokyo
National Institute of Infectious Diseases
Statistics
Citations: 13
Authors: 13
Affiliations: 4
Identifiers
Doi:
10.1002/jmv.20525
ISSN:
01466615
e-ISSN:
10969071
Research Areas
Genetics And Genomics
Infectious Diseases
Study Locations
Multi-countries
Ghana