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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Effect of nitazoxanide in persistent diarrhea and enteritis associated with Blastocystis hominis
Clinical Gastroenterology and Hepatology, Volume 3, No. 10, Year 2005
Notification
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Description
Background & Aims: The aim of this study was to evaluate the efficacy of nitazoxanide for the treatment of diarrhea and enteritis associated with Blastocystis hominis as the sole identified pathogen in children and adults from the Nile delta of Egypt. Methods: Two prospective, randomized, double-blind, placebo-controlled studies were conducted. Nitazoxanide 500 mg (as a 500-mg tablet) was administered twice daily for 3 days in patients aged 12 years or older, 200 mg (as 10 mL of an oral suspension) was administered twice daily for 3 days in patients aged 4-11 years, and 100 mg (as 5 mL of an oral suspension) was administered twice daily for 3 days in patients aged 1-3 years. Results: Four days after the completion of therapy, 36 (86%) of the 42 patients who received nitazoxanide showed resolution of symptoms compared with 16 (38%) of 42 patients who received placebo (P < .0001). Thirty-six (86%) of the 42 patients who received nitazoxanide were free of B hominis organisms in each of 3 posttreatment stool samples compared with only 5 (12%) of 42 patients who received placebo (P < .0001). Response rates in patients receiving the tablets and the suspension were identical. Conclusions: These findings suggest that B hominis is pathogenic in some patients and can be treated effectively with nitazoxanide. Alternatively, the possibility that nitazoxanide is effective in treating other unidentified causes of persistent diarrhea and enteritis warrants further study. © 2005 by the American Gastroenterological Association.
Authors & Co-Authors
Rossignol, Jean François A.
United States, Tampa
Romark Institute for Medical Research
Kabil, Samir M.
Egypt, Zagazig
Zagazig University
Said, Mohammed
Egypt, Zagazig
Zagazig University
Samir, Hatem
Egypt, Zagazig
Zagazig University
Younis, Azza Ibrahim H.
Egypt, Cairo
Faculty of Medicine
Statistics
Citations: 99
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1016/S1542-3565(05)00427-1
ISSN:
15423565
Research Areas
Disability
Health System And Policy
Maternal And Child Health
Study Design
Cohort Study
Study Locations
Egypt