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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Azithromycin prophylaxis against a chloroquine-resistant strain of Plasmodium falciparum
The Lancet, Volume 343, No. 8910, Year 1994
Notification
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Description
Azithromycin has antimalarial activity and favourable pharmacokinetic properties for a prophylactic antimalarial agent. We investigated the ability of azithromycin to prevent malaria in volunteers infected with a chloroquine-resistant strain of Plasmodium falciparum. 4 volunteers received oral azithromycin 500 mg followed by 250 mg daily for 7 further days. Subjects were infected on the third day of azithromycin.3 subjects were protected compared with none of 15 controls. The volunteer not protected by azithromycin had unquantifiable plasma levels of azithromycin, probably because of poor absorption. Azithromycin could be a promising prophylactic agent for P falciparum malaria. © 1994.
Authors & Co-Authors
Heppner, D. Gray
United States, Silver Spring
Walter Reed Army Institute of Research
Wellde, Bruce T.
United States, Silver Spring
Walter Reed Army Institute of Research
Schneider, Imogene
United States, Silver Spring
Walter Reed Army Institute of Research
Sadoff, Jerald C.
United States, Silver Spring
Walter Reed Army Institute of Research
Andersen, Steven L.
United States, Silver Spring
Walter Reed Army Institute of Research
Schuster, Brian G.
United States, Silver Spring
Walter Reed Army Institute of Research
Foulds, George
United States, New London
Pfizer Global Research and Development
Statistics
Citations: 50
Authors: 7
Affiliations: 2
Identifiers
Doi:
10.1016/S0140-6736(94)92526-7
ISSN:
01406736
Research Areas
Health System And Policy
Infectious Diseases