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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
Gene expression profiling and pathway analysis of human bronchial epithelial cells exposed to airborne particulate matter collected from Saudi Arabia
Toxicology and Applied Pharmacology, Volume 265, No. 2, Year 2012
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Description
Epidemiological studies have established a positive correlation between human mortality and increased concentration of airborne particulate matters (PM). However, the mechanisms underlying PM related human diseases, as well as the molecules and pathways mediating the cellular response to PM, are not fully understood. This study aims to investigate the global gene expression changes in human cells exposed to PM10 and to identify genes and pathways that may contribute to PM related adverse health effects. Human bronchial epithelial cells were exposed to PM10 collected from Saudi Arabia for 1 or 4days, and whole transcript expression was profiled using the GeneChip human gene 1.0 ST array. A total of 140 and 230 genes were identified that significantly changed more than 1.5 fold after PM10 exposure for 1 or 4days, respectively. Ingenuity Pathway Analysis revealed that different exposure durations triggered distinct pathways. Genes involved in NRF2-mediated response to oxidative stress were up-regulated after 1day exposure. In contrast, cells exposed for 4days exhibited significant changes in genes related to cholesterol and lipid synthesis pathways. These observed changes in cellular oxidative stress and lipid synthesis might contribute to PM related respiratory and cardiovascular disease. © 2012 Elsevier Inc.
Authors & Co-Authors
Sun, Hong
United States, New York
Nyu Grossman School of Medicine
Shamy, Magdy Y.
Saudi Arabia, Jeddah
King Abdulaziz University
Kluz, Thomas
United States, New York
Nyu Grossman School of Medicine
Muñoz, Alexandra B.
United States, New York
Nyu Grossman School of Medicine
Zhong, Mianhua
United States, New York
Nyu Grossman School of Medicine
Laulicht, Freda
United States, New York
Nyu Grossman School of Medicine
Alghamdi, Mansour A.
Saudi Arabia, Jeddah
King Abdulaziz University
Khoder, Mamdouh I.
Saudi Arabia, Jeddah
King Abdulaziz University
Chen, Lung Chi
United States, New York
Nyu Grossman School of Medicine
Costa, Max
United States, New York
Nyu Grossman School of Medicine
Statistics
Citations: 51
Authors: 10
Affiliations: 2
Identifiers
Doi:
10.1016/j.taap.2012.10.008
ISSN:
0041008X
e-ISSN:
10960333
Research Areas
Genetics And Genomics
Noncommunicable Diseases