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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Safety and Immunogenicity of Heterologous Prime-Boost Immunisation with Plasmodium falciparum Malaria Candidate Vaccines, ChAd63 ME-TRAP and MVA ME-TRAP, in Healthy Gambian and Kenyan Adults
PLoS ONE, Volume 8, No. 3, Article e57726, Year 2013
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Description
Background: Heterologous prime boost immunization with chimpanzee adenovirus 63 (ChAd63) and Modified vaccinia Virus Ankara (MVA) vectored vaccines is a strategy recently shown to be capable of inducing strong cell mediated responses against several antigens from the malaria parasite. ChAd63-MVA expressing the Plasmodium falciparum pre-erythrocytic antigen ME-TRAP (multiple epitope string with thrombospondin-related adhesion protein) is a leading malaria vaccine candidate, capable of inducing sterile protection in malaria naïve adults following controlled human malaria infection (CHMI). Methodology: We conducted two Phase Ib dose escalation clinical trials assessing the safety and immunogenicity of ChAd63-MVA ME-TRAP in 46 healthy malaria exposed adults in two African countries with similar malaria transmission patterns. Results: ChAd63-MVA ME-TRAP was shown to be safe and immunogenic, inducing high-level T cell responses (median >1300 SFU/million PBMC). Conclusions: ChAd63-MVA ME-TRAP is a safe and highly immunogenic vaccine regimen in adults with prior exposure to malaria. Further clinical trials to assess safety and immunogenicity in children and infants and protective efficacy in the field are now warranted. Trial Registration: Pactr.org PACTR2010020001771828 Pactr.org PACTR201008000221638 ClinicalTrials.gov NCT01373879 ClinicalTrials.gov NCT01379430. © 2013 Ogwang et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3602521/bin/pone.0057726.s001.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3602521/bin/pone.0057726.s002.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3602521/bin/pone.0057726.s003.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3602521/bin/pone.0057726.s004.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC3602521/bin/pone.0057726.s005.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3602521/bin/pone.0057726.s006.pdf
Authors & Co-Authors
Ogwang, Caroline
Kenya, Nairobi
Kenya Medical Research Institute
Afolabi, Muhammed Olanrewaju
Gambia, Banjul
Medical Research Council Laboratories Gambia
Kimani, Domtila
Kenya, Nairobi
Kenya Medical Research Institute
Jagne, Ya Jankey
Gambia, Banjul
Medical Research Council Laboratories Gambia
Sheehy, Susanne Helena
United Kingdom, Oxford
Churchill Hospital
Bliss, Carly M.
United Kingdom, Oxford
University of Oxford
Duncan, Christopher J.A.
United Kingdom, Oxford
Churchill Hospital
Collins, Katharine A.
United Kingdom, Oxford
University of Oxford
Garcia-Knight, Miguel Antonio
Kenya, Nairobi
Kenya Medical Research Institute
Kimani, Eva N.
Kenya, Nairobi
Kenya Medical Research Institute
Anagnostou, Nicholas A.
United Kingdom, Oxford
Churchill Hospital
Berrie, Eleanor L.
United Kingdom, Oxford
University of Oxford
Moyle, Sarah P.
United Kingdom, Oxford
University of Oxford
Gilbert, Sarah C.
United Kingdom, Oxford
University of Oxford
Spencer, Alexandra J.
United Kingdom, Oxford
University of Oxford
Soipei, Peninah
Kenya, Nairobi
Kenya Medical Research Institute
Mueller, Jenny
Gambia, Banjul
Medical Research Council Laboratories Gambia
Okebe, Joseph U.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Colloca, Stefano
Italy, Rome
Reithera Srl
Cortese, Riccardo
Italy, Rome
Reithera Srl
Italy, Naples
Ceinge-biotecnologie Avanzate S.c.a R.l.
Viebig, Nicola K.
Germany, Heidelberg
European Vaccine Initiative
Roberts, Rachel
United Kingdom, Oxford
Churchill Hospital
Gantlett, Katherine E.
United Kingdom, Oxford
Churchill Hospital
Lawrie, Alison M.
United Kingdom, Oxford
Churchill Hospital
Nicosia, Alfredo
Italy, Rome
Reithera Srl
Italy, Naples
Ceinge-biotecnologie Avanzate S.c.a R.l.
Italy, Naples
Università Degli Studi Di Napoli Federico Ii
Imoukhuede, Egeruan Babatunde
Germany, Heidelberg
European Vaccine Initiative
Bejon, Philip A.
Kenya, Nairobi
Kenya Medical Research Institute
Urban, Britta Christina
Kenya, Nairobi
Kenya Medical Research Institute
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Flanagan, Katie L.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Ewer, Katie J.
United Kingdom, Oxford
University of Oxford
Chilengi, Roma
Kenya, Nairobi
Kenya Medical Research Institute
Hill, Adrian V. S.
United Kingdom, Oxford
Churchill Hospital
United Kingdom, Oxford
University of Oxford
Bojang, Kalifa A.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Statistics
Citations: 33
Authors: 33
Affiliations: 9
Identifiers
Doi:
10.1371/journal.pone.0057726
e-ISSN:
19326203
Research Areas
Infectious Diseases
Maternal And Child Health