Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Extra-uterine myoid tumours in patients with acquired immunodeficiency syndrome: A clinicopathological reappraisal
Histopathology, Volume 59, No. 6, Year 2011
Notification
URL copied to clipboard!
Description
Aims: AIDS-associated myoid tumours (AIDS-MTs), often Epstein-Barr virus (EBV)-associated (EBV-positive MTs), include smooth muscle tumors (SMTs) and the relatively recently recognized myopericytomas (MPCTs). The myoid immunophenotype of AIDS-MTs has been documented inconsistently. The aim of this study was to reappraise the phenotypic and immunophenotypic features of extra-uterine AIDS-MTs and the clinical profile of afflicted patients. Methods and results: EBV early RNA in-situ hybridization testing on 27 AIDS-MTs from 25 patients identified 19 of 27 (70.4%) EBV-positive MTs and eight of 27 (29.6%) EBV-negative MTs. EBV-positive MTs comprised 12 of 19 EBV-positive SMTs [six leiomyomas, one smooth muscle tumour of uncertain malignant potential (STUMP), five leiomyosarcomas] and seven of 19 EBV-positive MPCTs [benign (five), malignant (two)]. The EBV-negative MTs, made up exclusively of EBV-negative SMTs, included angioleiomyoma (one), leiomyoma (one), STUMP (one) and leiomyosarcomas (five). Malignant AIDS-MTs demonstrated hypercellularity, pleomorphism, increased mitoses and necrosis. EBV-positive leiomyosarcomas retained a conspicuous fascicular architecture. Four of five EBV-negative leiomyosarcomas demonstrated marked pleomorphism. All EBV-positive MPCTs and two EBV-positive leiomyosarcomas contained aggregates of desmin-negative round and oval cells. Seventeen of 25 patients died, mainly from comorbid diseases. Conclusion: While the reappraised spectrum of AIDS-MTs does not demonstrate divergent subtype-determined clinical behaviour, heightened awareness/recognition of this expanded spectrum will not only promote improved diagnosis of pleomorphic and myopericytic variants, which may be the sentinel clue to AIDS and its comorbidity, but will also facilitate distinction from histopathological mimics in specific anatomic locations. © 2011 Blackwell Publishing Limited.
Authors & Co-Authors
Ramdial, Pratistadevi Kanaye
South Africa, Durban
University of Kwazulu-natal
South Africa, Durban
The Nelson R. Mandela Medical School
South Africa, Johannesburg
National Health Laboratory Service
Sing, Yetish
South Africa, Durban
University of Kwazulu-natal
South Africa, Durban
The Nelson R. Mandela Medical School
South Africa, Johannesburg
National Health Laboratory Service
Deonarain, Julian
South Africa, Durban
University of Kwazulu-natal
South Africa, Durban
The Nelson R. Mandela Medical School
South Africa, Johannesburg
National Health Laboratory Service
Vaubell, Jalaludin I.
South Africa, Durban
University of Kwazulu-natal
South Africa, Durban
The Nelson R. Mandela Medical School
South Africa, Johannesburg
National Health Laboratory Service
Naicker, Shaun
South Africa, Durban
University of Kwazulu-natal
South Africa, Durban
The Nelson R. Mandela Medical School
South Africa, Johannesburg
National Health Laboratory Service
Sydney, Clive
South Africa, Durban
University of Kwazulu-natal
South Africa, Johannesburg
National Health Laboratory Service
Hadley, Grenville Peter
South Africa, Durban
The Nelson R. Mandela Medical School
South Africa, Durban
University of Kwazulu-natal
Singh, Bhugwan N.
South Africa, Durban
The Nelson R. Mandela Medical School
South Africa, Durban
University of Kwazulu-natal
Kiratu, Erastus
South Africa, Durban
The Nelson R. Mandela Medical School
South Africa, Durban
University of Kwazulu-natal
Gundry, B. N.
South Africa, Durban
The Nelson R. Mandela Medical School
South Africa, Durban
University of Kwazulu-natal
Sewram, Vikash
South Africa, Tygerberg
South African Medical Research Council
Statistics
Citations: 18
Authors: 11
Affiliations: 4
Identifiers
Doi:
10.1111/j.1365-2559.2011.04049.x
ISSN:
03090167
e-ISSN:
13652559
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases