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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Meta-analysis of 32 genome-wide linkage studies of schizophrenia
Molecular Psychiatry, Volume 14, No. 8, Year 2009
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Description
A genome scan meta-a nalysis (GSMA) was carried out on 32 independent genome-wide linkage scan analyses that included 3255 pedigrees with 7413 genotyped cases affected with schizophrenia (SCZ) or related disorders. The primary GSMA divided the autosomes into 120 bins, rank-ordered the bins within each study according to the most positive linkage result in each bin, summed these ranks (weighted for study size) for each bin across studies and determined the empirical probability of a given summed rank (P SR) by simulation. Suggestive evidence for linkage was observed in two single bins, on chromosomes 5q (142-168 Mb) and 2q (103-134 Mb). Genome-wide evidence for linkage was detected on chromosome 2q (119-152 Mb) when bin boundaries were shifted to the middle of the previous bins. The primary analysis met empirical criteria for aggregate genome-wide significance, indicating that some or all of 10 bins are likely to contain loci linked to SCZ, including regions of chromosomes 1, 2q, 3q, 4q, 5q, 8p and 10q. In a secondary analysis of 22 studies of European-ancestry samples, suggestive evidence for linkage was observed on chromosome 8p (16-33 Mb). Although the newer genome-wide association methodology has greater power to detect weak associations to single common DNA sequence variants, linkage analysis can detect diverse genetic effects that segregate in families, including multiple rare variants within one locus or several weakly associated loci in the same region. Therefore, the regions supported by this meta-analysis deserve close attention in future studies. © 2009 Nature Publishing Group.
Authors & Co-Authors
Ng, M. Y.M.
United Kingdom, London
Guy's Hospital
Levinson, Douglas F.
United States, Palo Alto
Stanford University
Faraone, Stephen V.
United States, Syracuse
Suny Upstate Medical University
Suarez, Brian K.
United States, St. Louis
Washington University in St. Louis
DeLisi, Lynn Eleanor
United States, New York
Nyu Langone Health
United States, Orangeburg
Nathan S. Kline Institute for Psychiatric Research
Arinami, T.
Japan, Tsukuba
University of Tsukuba
Riley, Brien P.
United States, Richmond
Virginia Institute for Psychiatric and Behavioral Genetics
Paunio, Tiina
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Finland, Helsinki
Helsinki University Hospital
Pulver, Ann E.
United States, Baltimore
Johns Hopkins School of Medicine
Irmansyah, Irmansyah
Indonesia, Depok
Universitas Indonesia
Holmans, Peter A.
United Kingdom, Cardiff
Cardiff University
Escamilla, M.
United States, San Antonio
University of Texas Health Science Center at San Antonio
Wildenauer, Dieter B.
Australia, Perth
The Faculty of Health and Medical Sciences
Williams, Nigel M.
United Kingdom, Cardiff
Cardiff University
Laurent, Claudine
France, Paris
Sorbonne Université
Mowry, Bryan J.
Australia, Brisbane
The University of Queensland
Brzustowicz, L. M.
United States, New Brunswick
Rutgers University–new Brunswick
Maziade, M.
Canada, Quebec
Institut Universitaire en Santé Mentale de Québec
Sklar, Pamela
United States, Boston
Massachusetts General Hospital
Garver, D. L.
United States
Va Medical Center
Abecasis, Gonçalo R.
United States, Ann Arbor
University of Michigan School of Public Health
Lerer, Bernard
Israel, Jerusalem
Hadassah University Medical Centre
Fallin, M. D. Daniele
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Gurling, Hugh Malcolm Douglas
United Kingdom, London
University College London
Gejman, Pablo V.
United States, Evanston
Northshore University Healthsystem
Lindholm, Eva
Sweden, Uppsala
Uppsala Universitet
Moises, H. W.
Germany, Kiel
Christian-albrechts-universität zu Kiel
Byerley, William F.
United States, San Francisco
University of California, San Francisco
Wijsman, Ellen M.
United States, Seattle
University of Washington
Forabosco, P.
United Kingdom, London
Guy's Hospital
Tsuang, Ming T.
United States, La Jolla
Department of Psychiatry
United States, Cambridge
Harvard University
Hwu, Hai-Gwo Gwo
Taiwan, Taipei
National Taiwan University Hospital
Okazaki, Y.
Japan, Tokyo
Tokyo Metropolitan Matsuzawa Hospital
Kendler, Kenneth S.
United States, Richmond
Virginia Institute for Psychiatric and Behavioral Genetics
Wormley, Brandon K.
United States, Richmond
Virginia Institute for Psychiatric and Behavioral Genetics
Fanous, Ayman H.
United States
Va Medical Center
United States, Washington, D.c.
Georgetown University Medical Center
Walsh, Dermot B.
Iran, Dublin
The Health Research Board
O’neill, F. Anthony
United Kingdom, Belfast
Queen's University Belfast
Peltonen-Palotie, Leena Johanna
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Finland, Helsinki
Helsingin Yliopisto
United States, Cambridge
Massachusetts Institute of Technology
United Kingdom, Hinxton
Wellcome Sanger Institute
Nestadt, Gerald R.
United States, Baltimore
Johns Hopkins School of Medicine
Lasseter, Virginia K.
United States, Baltimore
Johns Hopkins School of Medicine
Liang, Kungyee
United States, Baltimore
Johns Hopkins University
Papadimitriou, George N.
Greece, Athens
School of Medicine
Dikeos, Dimitris G.
Greece, Athens
School of Medicine
Schwab, Sibylle G.
Australia, Perth
The Harry Perkins Institute of Medical Research
Australia, Perth
The University of Western Australia
Australia, Perth
University of Western Australia, School of Medicine and Pharmacology
Owen, Michael John
United Kingdom, Cardiff
Cardiff University
O'Donovan, Michael Conlon
United Kingdom, Cardiff
Cardiff University
Norton, N.
United Kingdom, Cardiff
Cardiff University
Hare, E.
United States, San Antonio
University of Texas Health Science Center at San Antonio
Raventós, H.
Costa Rica, San Jose
Universidad de Costa Rica
Nicolini, Humberto
Mexico, Mexico
Universidad Autónoma de la Ciudad de México
Albus, Margot I.
Germany, Haar Bei Munchen
Isar-amper-klinikum München-ost
Maier, Wolfgang
Germany, Bonn
Universität Bonn
Nimgaonkar, Vishwajit Laxmikant
United States, Pittsburgh
University of Pittsburgh
Terenius, L.
Sweden, Stockholm
Karolinska Universitetssjukhuset
Mallet, Jacques J.B.
France, Paris
Hôpital Universitaire Pitié Salpêtrière
Jay, Maurice
France, Paris
Sorbonne Université
Godard, Stephanie
France, Paris
Inserm
Nertney, Deborah A.
Australia, Brisbane
The University of Queensland
Alexander, M.
United States, Palo Alto
Stanford University
Crowe, R. R.
United States, Iowa City
University of Iowa
Silverman, Jeremy M.
United States, New York
Icahn School of Medicine at Mount Sinai
Bassett, A. S.
Canada, Toronto
University of Toronto
Roy, M. A.
Canada, Quebec
Institut Universitaire en Santé Mentale de Québec
Mérette, C.
Canada, Quebec
Institut Universitaire en Santé Mentale de Québec
Pato, Carlos N.
United States, Los Angeles
University of Southern California
Pato, Michèle T.
United States, Los Angeles
University of Southern California
Roos, J. L.
South Africa, Pretoria
University of Pretoria
Kohn, Y.
Israel, Jerusalem
Hadassah University Medical Centre
Amann-Zalcenstein, D.
Israel, Rehovot
Weizmann Institute of Science Israel
Kalsi, Gursharan
United Kingdom, London
University College London
McQuillin, Andrew
United Kingdom, London
University College London
Curtis, David
United Kingdom, London
Barts and the London School of Medicine and Dentistry
Brynjolfson, J.
Iceland, Reykjavik
General Hospital
Sigmundsson, Thordur
Iceland, Reykjavik
General Hospital
Petursson, Hannes
Iceland, Reykjavik
General Hospital
Sanders, Alan R.
United States, Evanston
Northshore University Healthsystem
Duan, Jubao
United States, Evanston
Northshore University Healthsystem
Jazin, Elena
Sweden, Uppsala
Uppsala Universitet
Myles-Worsley, M.
United States, Syracuse
Suny Upstate Medical University
Karayiorgou, Maria
United States, New York
Columbia University Irving Medical Center
Lewis, Cathryn M.
United Kingdom, London
Guy's Hospital
United Kingdom, London
Medical Research Council
Statistics
Citations: 82
Authors: 82
Affiliations: 63
Identifiers
Doi:
10.1038/mp.2008.135
ISSN:
13594184
e-ISSN:
14765578
Research Areas
Cancer
Genetics And Genomics
Mental Health
Study Approach
Systematic review