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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm
Nature Genetics, Volume 42, No. 8, Year 2010
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Description
We performed a genome-wide association study on 1,292 individuals with abdominal aortic aneurysms (AAAs) and 30,503 controls from Iceland and The Netherlands, with a follow-up of top markers in up to 3,267 individuals with AAAs and 7,451 controls. The A allele of rs7025486 on 9q33 was found to associate with AAA, with an odds ratio (OR) of 1.21 and P = 4.6 × 10 -10. In tests for association with other vascular diseases, we found that rs7025486[A] is associated with early onset myocardial infarction (OR = 1.18, P = 3.1 × 10-5), peripheral arterial disease (OR = 1.14, P = 3.9 × 10-5) and pulmonary embolism (OR = 1.20, P = 0.00030), but not with intracranial aneurysm or ischemic stroke. No association was observed between rs7025486[A] and common risk factors for arterial and venous diseasesĝ€"that is, smoking, lipid levels, obesity, type 2 diabetes and hypertension. Rs7025486 is located within DAB2IP, which encodes an inhibitor of cell growth and survival. © 2010 Nature America, Inc. All rights reserved.
Authors & Co-Authors
Grétarsdóttir, Sólveig
Iceland, Reykjavik
Decode Genetics
Baas, Annette F.
Netherlands, Utrecht
University Medical Center Utrecht
Thorleifsson, Gudmar
Iceland, Reykjavik
Decode Genetics
Hólm, Hilma
Iceland, Reykjavik
Decode Genetics
Den Heijer, Martin
Netherlands, Nijmegen
Radboud University Medical Center
De Vries, Jean Paul PM M.
Netherlands, Nieuwegein
St. Antonius Ziekenhuis
van Rij, Andrè M.
New Zealand, Dunedin
University of Otago
Williams, Michael J.A.
New Zealand, Dunedin
University of Otago
Kostic, Jelena Pop
Iceland, Reykjavik
Decode Genetics
Jonasdottir, Aslaug
Iceland, Reykjavik
Decode Genetics
Walters, G. Bragi
Iceland, Reykjavik
Decode Genetics
Másson, Gísli
Iceland, Reykjavik
Decode Genetics
Sulem, Patrick
Iceland, Reykjavik
Decode Genetics
Saemundsdottir, Jona
Iceland, Reykjavik
Decode Genetics
Tromp, Gerard C.
United States, Danville
Geisinger Medical Center
Elmore, James R.
United States, Danville
Geisinger Medical Center
Sakalihasan, Natzi
Belgium, Liege
Université de Liège
Defraigne, Jean Olivier
Belgium, Liege
Université de Liège
Ferrell, Robert E.
United States, Pittsburgh
University of Pittsburgh Graduate School of Public Health
Ronkainen, Antti
Finland, Kuopio
Kuopio University Hospital
Ruigrok, Ynte Marije
Netherlands, Utrecht
University Medical Center Utrecht
Wijmenga, Cisca
Netherlands, Groningen
Rijksuniversiteit Groningen
Grobbee, Diederick E Egbertus
Netherlands, Utrecht
University Medical Center Utrecht
Shah, Svati H.
United States, Durham
Duke University Medical Center
Granger, Christopher B.
United States, Durham
Duke Clinical Research Institute
Erdmann, Jeanette Ali
United States, Atlanta
Emory University School of Medicine
Patel, Riyaz S.
United States, Atlanta
Emory University School of Medicine
United Kingdom, Cardiff
Cardiff University
Levey, Aĺlan I.
United States, Atlanta
Emory University School of Medicine
Girelli, Domenico
Italy, Verona
Università Degli Studi Di Verona
Pignatti, P. F.
Italy, Verona
Università Degli Studi Di Verona
Olivieri, Oliviero
Italy, Verona
Università Degli Studi Di Verona
Martinelli, Nicola
Italy, Verona
Università Degli Studi Di Verona
Malerba, Giovanni A.
Italy, Verona
Università Degli Studi Di Verona
Trabetti, Elisabetta
Italy, Verona
Università Degli Studi Di Verona
Becker, Lewis C.
United States, Baltimore
Johns Hopkins University
Becker, Diane M.
United States, Baltimore
Johns Hopkins University
Reilly, Muredach P.
United States, Philadelphia
University of Pennsylvania Perelman School of Medicine
Rader, Daniel J.
United States, Philadelphia
University of Pennsylvania Perelman School of Medicine
Mueller, Thomas J.
Austria, Vienna
Medizinische Universität Wien
Lindblad, Bengt L.T.
Sweden, Lund
Skånes Universitetssjukhus
Gaetani, Eleonora
Italy, Rome
Università Cattolica Del Sacro Cuore, Facoltà Di Medicina e Chirurgia
Pola, Roberto
Italy, Rome
Università Cattolica Del Sacro Cuore, Facoltà Di Medicina e Chirurgia
United States, Boston
Caritas St. Elizabeth's Medical Center
Wells, Philip Stephen
Canada, Ottawa
L'hôpital D'ottawa
Corral, Javier M.
Spain, Murcia
Centro Regional de Hemodonacion
Grarup, Niels
Denmark, Gentofte
Hagedorn Research Institute
Jörgensen, Torben J.
Denmark, Glostrup
Amtssygehuset I Glostrup
Denmark, Copenhagen
Københavns Universitet
Witte, Daniel R.
Denmark, Herlev
Steno Diabetes Center Copenhagen
Hansen, Torben Frøstrup
Denmark, Gentofte
Hagedorn Research Institute
Denmark, Odense
Syddansk Universitet
Pedersen, Oluf Borbye
Denmark, Gentofte
Hagedorn Research Institute
Denmark, Copenhagen
Københavns Universitet
Aben, Katja K.H.
Netherlands, Nijmegen
Radboud University Medical Center
Netherlands, Nijmegen
Integraal Kankercentrum Oost
de Graaf, Jacqueline J.
Netherlands, Nijmegen
Radboud University Medical Center
Holewijn, Suzanne
Netherlands, Nijmegen
Radboud University Medical Center
Folkersen, Lasse
Sweden, Stockholm
Karolinska Institutet
Franco-Cereceda, Anders
Sweden, Stockholm
Karolinska Institutet
Eriksson, P. Ake
Sweden, Stockholm
Karolinska Institutet
Collier, David Andrew
United Kingdom, London
King's College London
Stefánsson, Hreinn
Iceland, Reykjavik
Decode Genetics
Steinthórsdóttir, Valgerdur
Iceland, Reykjavik
Decode Genetics
Rafnar, Thorunn
Iceland, Reykjavik
Decode Genetics
Valdimarsson, Einar Már
Iceland, Reykjavik
Landspitali - the National University Hospital of Iceland
Magnadóttir, Hulda Bra
United States, Lebanon
Upper Valley Neurology Neurosurgery
Sveinbjörnsdóttir, Sigurlaug
Iceland, Reykjavik
Landspitali - the National University Hospital of Iceland
Ólafsson, Ísleifur
Iceland, Reykjavik
Landspitali - the National University Hospital of Iceland
Magnússon, Magnús Karl
Iceland, Reykjavik
Landspitali - the National University Hospital of Iceland
Iceland, Reykjavik
Haskoli Islands
Haraldsdóttir, Vilhelmína
Iceland, Reykjavik
Landspitali - the National University Hospital of Iceland
Iceland, Reykjavik
Haskoli Islands
Andersen, Karl K.
Iceland, Reykjavik
Landspitali - the National University Hospital of Iceland
Iceland, Reykjavik
Haskoli Islands
Onundarson, Pall T.
Iceland, Reykjavik
Landspitali - the National University Hospital of Iceland
Iceland, Reykjavik
Haskoli Islands
Thorgeirsson, Gudmundur
Iceland, Reykjavik
Landspitali - the National University Hospital of Iceland
Iceland, Reykjavik
Haskoli Islands
Kiemeney, Lambertus A.L.M.
Netherlands, Nijmegen
Radboud University Medical Center
Powell, Janet Tinka
United Kingdom, London
Imperial College London
Carey, David J.
United States, Danville
Geisinger Medical Center
Kuivaniemi, Helena
United States, Danville
Geisinger Medical Center
Lindholt, J. Sanddal
Denmark, Viborg
Regionshospitalet Viborg
Jones, Gregory Thomas
New Zealand, Dunedin
University of Otago
Kong, Augustine
Iceland, Reykjavik
Decode Genetics
Blankensteijn, J. D.
Netherlands, Amsterdam
Amsterdam Umc - Vrije Universiteit Amsterdam
Netherlands, Nijmegen
Radboud University Medical Center
Matthíasson, Stefán E.
Iceland, Reykjavik
Haskoli Islands
Thorsteinsdottir, Unnur Arna
Iceland, Reykjavik
Decode Genetics
Iceland, Reykjavik
Haskoli Islands
Stefánsson, Kári
Iceland, Reykjavik
Decode Genetics
Iceland, Reykjavik
Haskoli Islands
Statistics
Citations: 167
Authors: 79
Affiliations: 47
Identifiers
Doi:
10.1038/ng.622
ISSN:
10614036
Research Areas
Genetics And Genomics
Noncommunicable Diseases
Study Design
Cohort Study
Case-Control Study