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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
T-cell telomere length maintained in HTV-infected long-term survivors
HIV Medicine, Volume 1, No. 2, Year 2000
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Description
Background and methods We have used the erosion of telomeric DNA as a measure of cellular division to study the replicative history of isolated T-lymphocyte subpopulations from a group of HIV-infected long-term survivors and age-matched healthy controls. Results In keeping with previous studies, we found that CD45RO+ (memory) T-cells showed greater telomere erosion than CD45RA+ (naive) T-cells. We did not, however, find any significant differences in the telomere lengths of isolated CD4+, CD8+, CD45RA+ or CD45RCT T-cells between HIV-infected long-term survivors and age-matched controls. Further, we found no evidence of telomerase activation in T-cells from the HIV-infected groups to account for the lack of telomere erosion. Conclusions Our data show no evidence, through telomere shortening, of clonal exhaustion or replicative senescence due to an increased rate of immune cell turnover in HIV-infected long-term survivors. © 2000 British HIV Association.
Authors & Co-Authors
Gilmour, Jill W.
United Kingdom, London
Chelsea and Westminster Hospital
Easterbrook, Philippa Jane
United Kingdom, Leicester
University of Leicester
Gotch, Frances M.
United Kingdom, Leicester
University of Leicester
United Kingdom, Liverpool
University of Liverpool
Browning, Michael J.
United Kingdom, London
Chelsea and Westminster Hospital
Statistics
Citations: 9
Authors: 4
Affiliations: 4
Identifiers
Doi:
10.1046/j.1468-1293.2000.00010.x
ISSN:
14642662
Research Areas
Genetics And Genomics
Infectious Diseases