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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Identification of quantitative trait loci affecting resistance to gastrointestinal parasites in a double backcross population of Red Maasai and Dorper sheep
Animal Genetics, Volume 43, No. 1, Year 2012
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Description
A genome-wide scan for quantitative trait loci (QTL) affecting gastrointestinal nematode resistance in sheep was completed using a double backcross population derived from Red Maasai and Dorper ewes bred to F 1 rams. This design provided an opportunity to map potentially unique genetic variation associated with a parasite-tolerant breed like Red Maasai, a breed developed to survive East African grazing conditions. Parasite indicator phenotypes (blood packed cell volume - PCV and faecal egg count - FEC) were collected on a weekly basis from 1064 lambs during a single 3-month post-weaning grazing challenge on infected pastures. The averages of last measurements for FEC (AVFEC) and PCV (AVPCV), along with decline in PCV from challenge start to end (PCVD), were used to select lambs (N = 371) for genotyping that represented the tails (10% threshold) of the phenotypic distributions. Marker genotypes for 172 microsatellite loci covering 25 of 26 autosomes (1560.7 cm) were scored and corrected by Genoprob prior to qxpak analysis that included Box-Cox transformed AVFEC and arcsine transformed PCV statistics. Significant QTL for AVFEC and AVPCV were detected on four chromosomes, and this included a novel AVFEC QTL on chromosome 6 that would have remained undetected without Box-Cox transformation methods. The most significant P-values for AVFEC, AVPCV and PCVD overlapped the same marker interval on chromosome 22, suggesting the potential for a single causative mutation, which remains unknown. In all cases, the favourable QTL allele was always contributed from Red Maasai, providing support for the idea that future marker-assisted selection for genetic improvement of production in East Africa will rely on markers in linkage disequilibrium with these QTL. © 2011 Stichting International Foundation for Animal Genetics.
Authors & Co-Authors
da Silva, Marcos Vinicius Barbosa
United States, Beltsville
Usda Ars Beltsville Agricultural Research Center
Brazil, Brasilia
Empresa Brasileira de Pesquisa Agropecuária - Embrapa
Sonstegard, Tad Stewart
United States, Beltsville
Usda Ars Beltsville Agricultural Research Center
Hanotte, Olivier H.
Kenya, Nairobi
International Livestock Research Institute Nairobi
United Kingdom, Nottingham
University of Nottingham
Mugambi, John M.
Kenya, Nairobi
International Livestock Research Institute Nairobi
Kenya
Veterinary Research Centre Kari
Garcia, José Fernando
Brazil, Sao Paulo
Universidade Estadual Paulista Júlio de Mesquita Filho
Austria, Vienna
International Atomic Energy Agency, Vienna
Nagda, Sonal N.
Kenya, Nairobi
International Livestock Research Institute Nairobi
Gibson, J. P.
Kenya, Nairobi
International Livestock Research Institute Nairobi
Australia, Armidale
University of new England Australia
Iraqi, Fuad A.
Kenya, Nairobi
International Livestock Research Institute Nairobi
Israel, Tel Aviv-yafo
Tel Aviv University
McClintock, A. E.
Kenya, Nairobi
International Livestock Research Institute Nairobi
Kemp, Stephen J.
Kenya, Nairobi
International Livestock Research Institute Nairobi
Boettcher, Paul J.
Austria, Vienna
International Atomic Energy Agency, Vienna
Malek, Md. Abdul
Austria, Vienna
International Atomic Energy Agency, Vienna
Van Tassell, Curtis Paul
United States, Beltsville
Usda Ars Beltsville Agricultural Research Center
Baker, Robert Leyden
Kenya, Nairobi
International Livestock Research Institute Nairobi
Statistics
Citations: 52
Authors: 14
Affiliations: 9
Identifiers
Doi:
10.1111/j.1365-2052.2011.02202.x
ISSN:
02689146
e-ISSN:
13652052
Research Areas
Cancer
Genetics And Genomics
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
Multi-countries